Enberg N, Alho H, Loimaranta V, Lenander-Lumikari M
Institute of Dentistry, Turku Immunology Centre and Department of Cariology, University of Turku, Finland.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Sep;92(3):292-8. doi: 10.1067/moe.2001.116814.
The aim of our study was to evaluate the effects of acute alcohol consumption on saliva secretion rate and selected salivary parameters in healthy nonalcoholic volunteers.
Twenty-four volunteers (37.7 +/- 9.6 years, mean +/- SD) consumed 0.6 g or 0.7 g alcohol/kg of body weight (for women and men, respectively) in a soft drink. Saliva samples were collected, first (S0) before any alcohol was consumed, 45 minutes after consumption (S1) and, finally, 60 minutes after S1 (S2). Flow rates of both resting whole saliva and paraffin-stimulated (SWS) whole saliva were assessed. SWS was assessed for amylase, total protein, inorganic phosphate (PO4(3-)), sodium (Na+), potassium (K+), and calcium (Ca2+) content.
SWS, but not resting whole saliva (in milliliters/minute), decreased significantly after consumption of alcohol. Amylase activity (P =.010) and the concentrations of Na+ (P =.000) and Ca2+ (P =.002) decreased significantly between S0 and S1. When SWS was analyzed for output, the total protein concentration (S0 to S1, P =.000; S0 to S2, P =.033) and amylase activity (S0 to S1, P =.000) decreased significantly. Further, the output of all the studied electrolytes decreased significantly as blood alcohol concentration increased.
We conclude that acute alcohol consumption causes a decrease in SWS flow rate. The decrease in flow rate also results in impaired output of total protein and amylase, as well as in a decrease in the output of electrolytes.
本研究旨在评估急性饮酒对健康非酒精性志愿者唾液分泌率及选定唾液参数的影响。
24名志愿者（年龄37.7±9.6岁，均值±标准差）在软饮料中分别摄入0.6 g或0.7 g/千克体重的酒精（女性和男性分别如此）。在饮用任何酒精之前采集唾液样本（S0），饮用后45分钟采集（S1），最后在S1后60分钟采集（S2）。评估静息全唾液和石蜡刺激后的全唾液（SWS）的流速。对SWS评估淀粉酶、总蛋白、无机磷酸盐（PO4(3-)）、钠（Na+）、钾（K+）和钙（Ca2+）的含量。
饮酒后SWS流速显著下降，但静息全唾液流速（毫升/分钟）未下降。在S0和S1之间，淀粉酶活性（P = 0.010）以及Na+（P = 0.000）和Ca2+（P = 0.002）的浓度显著降低。当分析SWS的输出量时，总蛋白浓度（S0至S1，P = 0.000；S0至S2，P = 0.033）和淀粉酶活性（S0至S1，P = 0.000）显著降低。此外，随着血液酒精浓度升高，所有研究的电解质输出量均显著下降。
我们得出结论，急性饮酒会导致SWS流速下降。流速下降还会导致总蛋白和淀粉酶输出受损，以及电解质输出减少。
