Department of Medical Oncology, Sydney Cancer Centre, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
Clin Pharmacol Ther. 2010 Apr;87(4):504-8. doi: 10.1038/clpt.2009.254. Epub 2010 Feb 10.
The link between chronic inflammation and increased risk of developing some cancers is well established. The molecular mechanisms that underlie this process (cause) as well as the chronic inflammation that accompanies cancer (consequence) continue to be elucidated. Cancer-associated inflammation has effects on the ability of cancers to metastasize, on the clinical manifestations of cancer, and on the ability of the patient to tolerate anticancer therapy. The identification of biomarkers of cancer-associated inflammation will assist in identifying patients at risk of its consequences.
慢性炎症与某些癌症风险增加之间的联系已得到充分证实。导致这一过程的分子机制以及伴随癌症发生的慢性炎症仍在不断阐明。癌症相关炎症会影响癌症转移的能力、癌症的临床表现以及患者耐受抗癌治疗的能力。癌症相关炎症生物标志物的鉴定将有助于识别有发生其后果风险的患者。
