Universidad Europea de Madrid, Biomedicine, Madrid, Spain.
Int J Sports Med. 2010 Apr;31(4):221-4. doi: 10.1055/s-0030-1247529. Epub 2010 Feb 10.
We studied the association of ACE and ACTN3 polymorphisms with skeletal muscle phenotypes (i. e. upper and lower body muscular strength and functional tests) in Spanish nonagenarian subjects [n=41, 33 women, 8 men, age: 90-97 years]. Mean values of the study phenotypes were not significantly different (all P>0.05) between ACE and ACTN3 genotypes. The analyses of the combined effects between genotypes ( ACE DD & ACTN3 RR/RX vs. ACE II/ID & ACTN3 XX) did not yield any significant difference. Our data suggest that, in the elderly, the influence of genetic factors on muscle phenotype traits is not reducible to a few single polymorphisms, including ACE and ACTN3 variants.
我们研究了 ACE 和 ACTN3 多态性与西班牙 90 岁以上老年人（n=41，33 名女性，8 名男性，年龄：90-97 岁）骨骼肌表型（即上肢和下肢肌肉力量及功能测试）之间的关联。研究表型的平均值在 ACE 和 ACTN3 基因型之间没有显著差异（所有 P 值均>0.05）。基因型（ACE DD 和 ACTN3 RR/RX 与 ACE II/ID 和 ACTN3 XX）之间的联合效应分析没有产生任何显著差异。我们的数据表明，在老年人中，遗传因素对肌肉表型特征的影响不能简化为少数几个单一的多态性，包括 ACE 和 ACTN3 变异。
