双相情感障碍患者静止期纹状体多巴胺转运体升高：[Tc] TRODAT-1 SPECT 研究。
Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1.
机构信息
Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan.
出版信息
Bipolar Disord. 2010 Feb;12(1):102-6. doi: 10.1111/j.1399-5618.2009.00771.x.
OBJECTIVES
Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.
METHODS
Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1.
RESULTS
Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT.
CONCLUSIONS
Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.
目的
多巴胺与双相情感障碍的病因有关。本研究旨在探讨处于缓解期的双相情感障碍患者纹状体多巴胺转运体（DAT）的可利用性。
方法
招募了 17 名未服用药物的处于缓解期的双相情感障碍患者。使用单光子发射计算机断层扫描（SPECT）和 [99mTc] TRODAT-1 来评估 DAT 的可利用性。
结果
与对照组相比，处于缓解期的双相情感障碍患者的纹状体 DAT 可利用性显著更高。
结论
即使在缓解期，DAT 的可利用性仍高于对照组。
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