Allgoewer Ingrid, Hoecht Stefan
Animal Eye Practice, Lindenthaler Allee 9, 14163 Berlin, Germany.
Vet Ophthalmol. 2010 Jan;13(1):20-5. doi: 10.1111/j.1463-5224.2009.00750.x.
To evaluate the effect of soft X-ray therapy in the treatment of refractory chronic superficial keratitis (CSK).
Thirteen dogs with severe CSK, that had been refractory to prior medical and/or surgical therapy were treated with soft X-ray therapy.
Both corneas of each dog were irradiated with soft X-rays (15 kV), to a total dose of 30 Gy, administered as two fractions over 48-96 h. Treatment was carried out under deep sedation in all dogs. Three dogs were treated by superficial lamellar keratectomy 48 h prior to radiotherapy. Changes in the extent of corneal pigmentation, pigment density and corneal vascularization were documented using a semi-quantitative grading scheme, schematic drawings and clinical photographs.
Only minor, transient adverse effects of treatment, such as photophobia, epiphora and blepharitis were noted. Overall the effect of soft X-rays on the course of the keratitis was superior when compared to the effect of Sr-90 irradiation that had been determined in a previous study.
Soft X-ray irradiation combined with keratectomy is a safe and effective new treatment option for severe and advanced CSK with significant visual impairment due to corneal pathology.
评估软X线疗法治疗难治性慢性浅层角膜炎（CSK）的效果。
13只患有严重CSK且先前药物和/或手术治疗无效的犬接受软X线疗法治疗。
对每只犬的双眼角膜进行软X线（15 kV）照射，总剂量30 Gy，分两次在48 - 96小时内给予。所有犬均在深度镇静下进行治疗。3只犬在放疗前48小时接受浅层板层角膜切除术。使用半定量分级方案、示意图和临床照片记录角膜色素沉着程度、色素密度和角膜血管化的变化。
仅观察到治疗的轻微、短暂不良反应，如畏光、流泪和睑缘炎。总体而言，与先前研究中确定的锶-90照射效果相比，软X线对角膜炎病程的影响更佳。
对于因角膜病变导致严重视力损害的重度和晚期CSK，软X线照射联合角膜切除术是一种安全有效的新治疗选择。
