Samie A, Barrett L J, Bessong P O, Ramalivhana J N, Mavhandu L G, Njayou M, Guerrant R L
AIDS Virus Research Laboratory, Department of Microbiology, University of Venda Private Bag X5050, Thohoyandou 0950, Limpopo Province, South Africa.
Ann Trop Med Parasitol. 2010 Jan;104(1):55-63. doi: 10.1179/136485910X12607012373911.
In a recent study in northern South Africa, the seroprevalence of Entamoeba histolytica infection among 257 HIV-positive and 117 HIV-negative individuals was determined, using an ELISA for the detection of antibodies reacting with the parasite's galactose/-acetyl-D-galactosamine(Gal/GalNAc)-inhibitable adherence lectin. Overall, 34.0% of the 374 participants (36.1% of the females and 28.1% of the males) were found seropositive for E. histolytica. Although all age-groups were affected by the amoebic pathogen, the subjects aged 50-59 years had the highest seroprevalence (69.2%). The seroprevalence of E. histolytica was also significantly higher among the HIV-positive subjects than among the HIV-negative (42.8% v. 14.5%; chi(2)=28.65; P<0.0001). Among the HIV-positive subjects, those with fewer than 200 CD4+ cells/microl were relatively more likely to be seropositive for E. histolytica (60.3% v. 43.8%; chi(2)=4.016; P=0.045). This is the first report indicating a positive association between E. histolytica infection and HIV in South Africa. Further studies, for example to determine the occurrence of diarrhoea or liver abscess in the study area, in relation to seropositivity for E. histolytica and/or HIV, are now needed.
在南非北部最近的一项研究中，采用酶联免疫吸附测定法（ELISA）检测与溶组织内阿米巴寄生虫的半乳糖/ N - 乙酰 - D - 半乳糖胺（Gal / GalNAc）抑制性黏附凝集素发生反应的抗体，从而确定了257名艾滋病毒阳性个体和117名艾滋病毒阴性个体中溶组织内阿米巴感染的血清阳性率。总体而言，374名参与者中有34.0%（女性为36.1%，男性为28.1%）被发现溶组织内阿米巴血清呈阳性。尽管所有年龄组均受到这种阿米巴病原体的影响，但年龄在50 - 59岁之间的受试者血清阳性率最高（69.2%）。溶组织内阿米巴的血清阳性率在艾滋病毒阳性受试者中也显著高于艾滋病毒阴性受试者（42.8%对14.5%；卡方=28.65；P<0.0001）。在艾滋病毒阳性受试者中，CD4 +细胞计数低于200个/微升的个体溶组织内阿米巴血清呈阳性的可能性相对更高（60.3%对43.8%；卡方=4.016；P = 0.045）。这是南非第一份表明溶组织内阿米巴感染与艾滋病毒之间存在正相关的报告。现在需要进一步开展研究，例如确定研究区域内腹泻或肝脓肿的发生情况与溶组织内阿米巴和/或艾滋病毒血清阳性之间的关系。
