Kalichman L, Malkin I, Belkin V, Batsevich V, Kobyliansky E
Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
Homo. 2010 Apr;61(2):117-29. doi: 10.1016/j.jchb.2010.01.047. Epub 2010 Feb 9.
A study was undertaken to evaluate whether various ethno-territorial samples have different characteristics of radiographic hand osteoarthritis (OA) and to evaluate whether climate is associated with differences in hand OA characteristics. The total sample included 4775 individuals (2220 males and 2555 females), belonging to 12 sub-samples, including 9 ethnic groups, from 10 geographic locations in the former USSR. Ethnicity, latitude, longitude, and climatic parameters (mean temperatures, humidity, and day length of January and July) were collected for each sample. X-rays of the left hand were obtained from each individual. Prevalence of hand OA was evaluated in four age groups (36-40, 41-45, 46-50, and 51-55 years). Using maximum likelihood estimation, the following characters were determined: the mean age of persons having 1 and 5 affected joints--A(m1) and A(m5), and the mean time in which one additional joint was affected--T(m). The difference between samples was evaluated using the chi(2)-test. The associations between hand OA, and climate were evaluated using Pearson's correlations. Significant differences in OA characteristics among samples were found. Prevalence of hand OA in the age-group 46-50 showed significant association with longitude (r=0.57, p=0.05) and inter-seasonal temperature amplitude (r=0.77, p=0.0035) and significant negative association with mean temperature of January (r=-0.72, p=0.0089). Significant associations were found between longitude, the mean temperature of January, and inter-seasonal temperature amplitude and age-related hand OA parameters (A(m1) and A(m5)). The present study indicates that the differences in characteristics of radiographic hand OA among samples are most likely associated with climatic variation.
开展了一项研究，以评估不同的民族地域样本是否具有不同的手部放射学骨关节炎（OA）特征，并评估气候是否与手部OA特征的差异相关。总样本包括4775人（2220名男性和2555名女性），属于12个子样本，包括来自前苏联10个地理位置的9个种族群体。为每个样本收集了种族、纬度、经度和气候参数（1月和7月的平均温度、湿度和日长）。从每个个体获取左手的X射线。在四个年龄组（36 - 40岁、41 - 45岁、46 - 50岁和51 - 55岁）中评估手部OA的患病率。使用最大似然估计，确定了以下特征：有1个和5个受累关节的人的平均年龄——A(m1)和A(m5)，以及另外一个关节受累的平均时间——T(m)。使用卡方检验评估样本之间的差异。使用Pearson相关性评估手部OA与气候之间的关联。发现样本之间OA特征存在显著差异。46 - 50岁年龄组的手部OA患病率与经度（r = 0.57，p = 0.05）和季节间温度幅度（r = 0.77，p = 0.0035）呈显著正相关，与1月平均温度呈显著负相关（r = -0.72，p = 0.0089）。发现经度、1月平均温度和季节间温度幅度与年龄相关的手部OA参数（A(m1)和A(m5)）之间存在显著关联。本研究表明，样本之间手部放射学OA特征的差异很可能与气候变化有关。
