Tarragó Castellanos Rosario, Mendoza Delgado Maria, Ruiz Valderrama Lorena, Arrieta Cruz Isabel, Cortés Barberena Edith, Morales Otal Adriana, Rodríguez Tobón Ernesto, Rodríguez Tobón Ahiezer, Olvera Ramírez Javier, Arenas Ríos Edith
Departamento de Biología de la Reproducción, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Ciudad de México 09340, Mexico.
Maestría en Biología de la Reproducción Animal, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Ciudad de México 09340, Mexico.
Life (Basel). 2025 Jun 14;15(6):959. doi: 10.3390/life15060959.
Obesity is considered a metabolic disease, in which leptin is used as an indicator of energy in the body. This hormone, in turn, is related to the neuroendocrine regulation of the reproductive axis. However, leptin excess secretion due to obesity can have a negative effect on reproduction. Overweight and obesity were induced through high-calorie diets. Lee and gonadosomatic indices were determined to characterize the model and degree of reproductive development in the testis and epididymis. Sperm quality was analyzed using spermatobioscopy. Morphometry was analyzed through histological analysis. The changes described affect testicular function in hormone and sperm production. Exposure of 3-month-old male rats to diets with different fat contents (10% and 60%) induced both overweight and obesity. The animals showed morphological alterations, both testicular and epididymal, the latter being more sensitive to dietary changes by modifying the epididymal index, morphometric parameters (in both organs), and a decrease in cilia length. These changes induced a reduction in sperm viability, as well as an increase in malformed spermatozoa. In conclusion, both overweight and obesity have effects on male reproduction by modifying the morphology and physiology of reproductive organs.
肥胖被认为是一种代谢性疾病，其中瘦素被用作体内能量的指标。反过来，这种激素与生殖轴的神经内分泌调节有关。然而，肥胖导致的瘦素分泌过多会对生殖产生负面影响。通过高热量饮食诱导超重和肥胖。测定李氏指数和性腺体指数以表征睾丸和附睾的生殖发育模型及程度。使用精子显微镜检查分析精子质量。通过组织学分析进行形态测量分析。上述变化影响睾丸在激素分泌和精子生成方面的功能。将3个月大的雄性大鼠暴露于不同脂肪含量（10%和60%）的饮食中会导致超重和肥胖。动物出现了睾丸和附睾的形态学改变，附睾对饮食变化更敏感，表现为附睾指数、形态测量参数（在两个器官中）发生改变，以及纤毛长度缩短。这些变化导致精子活力降低以及畸形精子增多。总之，超重和肥胖均通过改变生殖器官的形态和生理功能对雄性生殖产生影响。
