从巴戟天中提取的新型抗疟苯丙素共轭环烯醚萜。
New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides.
机构信息
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
出版信息
Bioorg Med Chem Lett. 2010 Mar 1;20(5):1520-3. doi: 10.1016/j.bmcl.2010.01.095. Epub 2010 Jan 25.
PMID:20149652
Abstract
A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation.
摘要
从传统上用于治疗疟疾的非洲国家的药用植物菝葜中分离得到了一种新的苯丙素共轭环烯醚萜类化合物，以及四种已知的同系物，通过生物测定指导分离作为抗疟原虫的原则。此外，通过改进的 Mosher 法和化学相关联，明确确定了它们的绝对立体结构。
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