Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.
Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania.
J Nat Prod. 2020 Sep 25;83(9):2641-2646. doi: 10.1021/acs.jnatprod.0c00447. Epub 2020 Aug 27.
The new 2,3-secoiridoids morisecoiridoic acids A () and B (), the new iridoid 8-acetoxyepishanzilactone (), and four additional known iridoids (-) were isolated from the leaf and stem bark methanol extracts of using chromatographic methods. The structure of shanzilactone () was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds - and (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite (3D7).
从 叶片和茎皮甲醇提取物中，采用色谱法分离得到了新的 2,3-裂环环烯醚萜 morisecoiridoic 酸 A () 和 B (), 新的裂环环烯醚萜 8-乙酰氧基epishanzilactone (), 和另外四个已知的裂环环烯醚萜 (-)。对 shanzilactone () 的结构进行了修订。通过 NMR 光谱和质谱技术鉴定了纯化的代谢产物，通过单晶 X 射线衍射分析确定了 的绝对构型。粗叶提取物（10 μg/mL）和化合物 - 和 （10 μM）对氯喹敏感的疟原虫 （3D7）表现出温和的抗疟活性。
