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脊椎动物和无脊椎动物中突触可塑性的共同机制。

Common mechanisms of synaptic plasticity in vertebrates and invertebrates.

机构信息

Department of Physiological Science, UCLA College, University of California, Los Angeles, Los Angeles, CA 90095-1606, USA.

出版信息

Curr Biol. 2010 Jan 12;20(1):R31-6. doi: 10.1016/j.cub.2009.10.023.

Abstract

Until recently, the literature on learning-related synaptic plasticity in invertebrates has been dominated by models assuming plasticity is mediated by presynaptic changes, whereas the vertebrate literature has been dominated by models assuming it is mediated by postsynaptic changes. Here I will argue that this situation does not reflect a biological reality and that, in fact, invertebrate and vertebrate nervous systems share a common set of mechanisms of synaptic plasticity.

摘要

直到最近,有关无脊椎动物学习相关突触可塑性的文献主要基于假设可塑性是由突触前变化介导的模型,而脊椎动物文献则主要基于假设可塑性是由突触后变化介导的模型。在这里,我将认为这种情况并不反映生物学现实,事实上,无脊椎动物和脊椎动物神经系统共享一套共同的突触可塑性机制。

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