逆行信使对突触的活动依赖性调节。
Activity-dependent regulation of synapses by retrograde messengers.
作者信息
Regehr Wade G, Carey Megan R, Best Aaron R
机构信息
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Neuron. 2009 Jul 30;63(2):154-70. doi: 10.1016/j.neuron.2009.06.021.
Abstract
Throughout the brain, postsynaptic neurons release substances from their cell bodies and dendrites that regulate the strength of the synapses they receive. Diverse chemical messengers have been implicated in retrograde signaling from postsynaptic neurons to presynaptic boutons. Here, we provide an overview of the signaling systems that lead to rapid changes in synaptic strength. We consider the capabilities, specializations, and physiological roles of each type of signaling system.
摘要
在整个大脑中，突触后神经元从其细胞体和树突释放物质，这些物质调节它们所接收突触的强度。多种化学信使参与了从突触后神经元到突触前终扣的逆行信号传递。在这里，我们概述了导致突触强度快速变化的信号系统。我们考虑了每种信号系统的能力、特性和生理作用。
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