与学习相关的突触可塑性：长时程增强和长时程抑制。

Learning-related synaptic plasticity: LTP and LTD.

作者信息

Siegelbaum S A, Kandel E R

机构信息

Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032.

出版信息

Curr Opin Neurobiol. 1991 Jun;1(1):113-20. doi: 10.1016/0959-4388(91)90018-3.

DOI:10.1016/0959-4388(91)90018-3

PMID:1822291

Abstract

The past several years have seen studies of synaptic plasticity in both invertebrate and vertebrate nervous systems come of age and lead to important new findings. In particular, current evidence points to a possible presynaptic site for long-term potentiation and the involvement of a retrograde messenger from the postsynaptic neuron. Recent advances in both cerebellar and cortical forms of long-term depression are also discussed.

摘要

在过去几年中，对无脊椎动物和脊椎动物神经系统突触可塑性的研究已经成熟，并带来了重要的新发现。特别是，目前的证据指向了长时程增强可能的突触前位点，以及来自突触后神经元的逆行信使的参与。本文还讨论了小脑和皮层形式的长时程抑制的最新进展。