Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Gastrointest Endosc. 2010 Feb;71(2):280-6. doi: 10.1016/j.gie.2009.09.031.
Capsule endoscopy (CE) has been widely used in clinical practice.
To provide systematically pooled results on the indications and detection, completion, and retention rates of small-bowel CE.
A systematic review.
We searched the PubMed database (2000-2008) for original articles relevant to small-bowel CE for the evaluation of patients with small-bowel signs and symptoms. Data on the total number of capsule procedures, the distribution of different indications for the procedures, the percentages of procedures with positive detection (detection rate), complete examination (completion rate), or capsule retention (retention rate) were extracted and/or calculated, respectively. In addition, the detection, completion, and retention rates were also extracted and/or calculated in relation to indications such as obscure GI bleeding (OGIB), definite or suspected Crohn's disease (CD), and neoplastic lesions.
A total of 227 English-language original articles involving 22,840 procedures were included. OGIB was the most common indication (66.0%), followed by the indication of only clinical symptoms reported (10.6%), and definite or suspected CD (10.4%). The pooled detection rates were 59.4%; 60.5%, 55.3%, and 55.9%, respectively, for overall, OGIB, CD, and neoplastic lesions. Angiodysplasia was the most common reason (50.0%) for OGIB. The pooled completion rate was 83.5%, with the rates being 83.6%, 85.4%, and 84.2%, respectively, for the 3 indications. The pooled retention rates were 1.4%, 1.2%, 2.6%, and 2.1%, respectively, for overall and the 3 indications.
Inclusion and exclusion criteria were loosely defined.
The pooled detection, completion, and retention rates are acceptable for total procedures. OGIB is the most common indication for small-bowel CE, with a high detection rate and low retention rate. In addition, angiodysplasia is the most common finding in patients with OGIB. A relatively high retention rate is associated with definite or suspected CD and neoplasms.
胶囊内镜（CE）已广泛应用于临床实践。
提供系统的汇总结果，说明小肠 CE 的适应证、检测、完成和保留率。
系统评价。
我们检索了 2000 年至 2008 年期间与小肠 CE 评估小肠症状和体征患者相关的原始文章，这些原始文章均来自 PubMed 数据库。分别提取并/或计算胶囊检查总例数、不同适应证的分布、阳性检出率（检出率）、完全检查率（完成率）或胶囊保留率（保留率）。此外，还分别提取并/或计算了与不明原因胃肠道出血（OGIB）、明确或疑似克罗恩病（CD）和肿瘤病变等适应证相关的检出率、完成率和保留率。
共纳入 227 篇英文原始文章，涉及 22840 例患者。OGIB 是最常见的适应证（66.0%），其次是仅报告临床症状的适应证（10.6%）和明确或疑似 CD（10.4%）。总的、OGIB、CD 和肿瘤病变的累积检出率分别为 59.4%、60.5%、55.3%和 55.9%。OGIB 最常见的原因是血管发育不良（50.0%）。总的完成率为 83.5%，3 种适应证的完成率分别为 83.6%、85.4%和 84.2%。总的和 3 种适应证的累积保留率分别为 1.4%、1.2%、2.6%和 2.1%。
纳入和排除标准定义较为宽松。
总的来说，胶囊内镜的累积检出率、完成率和保留率是可以接受的。OGIB 是小肠 CE 最常见的适应证，其检出率高，保留率低。此外，血管发育不良是 OGIB 患者最常见的发现。明确或疑似 CD 和肿瘤与相对较高的保留率相关。
