Suzuki Keisuke, Jayasena Channa N, Bloom Stephen R
Section of Investigative Medicine, Imperial College London, London W12 0NN, UK.
J Obes. 2011;2011:528401. doi: 10.1155/2011/528401. Epub 2011 Sep 22.
Obesity has received much attention worldwide in association with an increased risk of cardiovascular diseases, diabetes, and cancer. At present, bariatric surgery is the only effective treatment for obesity in which long-term weight loss is achieved in patients. By contrast, pharmacological interventions for obesity are usually followed by weight regain. Although the exact mechanisms of long-term weight loss following bariatric surgery are yet to be fully elucidated, several gut hormones have been implicated. Gut hormones play a critical role in relaying signals of nutritional and energy status from the gut to the central nervous system, in order to regulate food intake. Cholecystokinin, peptide YY, pancreatic polypeptide, glucagon-like peptide-1, and oxyntomodulin act through distinct yet synergistic mechanisms to suppress appetite, whereas ghrelin stimulates food intake. Here, we discuss the role of gut hormones in the regulation of food intake and body weight.
肥胖与心血管疾病、糖尿病和癌症风险增加相关，已在全球范围内受到广泛关注。目前，减肥手术是治疗肥胖的唯一有效方法，可使患者实现长期体重减轻。相比之下，肥胖的药物干预通常会导致体重反弹。尽管减肥手术后长期体重减轻的确切机制尚未完全阐明，但几种肠道激素与之有关。肠道激素在将营养和能量状态信号从肠道传递到中枢神经系统以调节食物摄入方面起着关键作用。胆囊收缩素、肽YY、胰多肽、胰高血糖素样肽-1和胃泌酸调节素通过不同但协同的机制发挥作用以抑制食欲，而胃饥饿素则刺激食物摄入。在此，我们讨论肠道激素在食物摄入和体重调节中的作用。
