Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.
Physiol Behav. 2010 Apr 26;100(1):67-75. doi: 10.1016/j.physbeh.2010.01.039. Epub 2010 Feb 10.
High dairy intakes have been associated with lower rates of obesity in observational studies, but mechanisms to explain the association are lacking. A high intake of dairy protein reduces spontaneous food intake and may be one important mechanism, but more specific effects of dairy calcium seem to exist. We have found that high versus low calcium intakes from dairy products had no effect on 24-h energy expenditure or substrate oxidation rates, but fecal fat excretion increased approximately 2.5-fold on the high-calcium diets. In a meta-analysis of intervention studies we found that increasing dairy calcium intake by 1200mg/day resulted in increased fecal fat excretion by 5.2 (1.6-8.8) g/day. Newer research shows that humans possess taste receptors for calcium in the gastrointestinal tract and that signaling may be linked to appetite regulation. A new line of evidence suggests that an inadequate calcium intake during an energy restricted weight loss program may trigger hunger and impair compliance to the diet. These mechanisms may be part of the explanation for the protective effects of dairy products with regard to obesity and metabolic syndrome.
高乳制品摄入量与观察性研究中较低的肥胖率有关,但缺乏解释这种关联的机制。大量摄入乳制品蛋白可减少自发性食物摄入,这可能是一个重要机制,但乳制品钙似乎具有更具体的作用。我们发现,来自乳制品的高钙与低钙摄入对 24 小时能量消耗或底物氧化率没有影响,但高钙饮食使粪便脂肪排泄量增加了约 2.5 倍。在干预研究的荟萃分析中,我们发现每天增加 1200 毫克的乳制品钙摄入可使粪便脂肪排泄量增加 5.2(1.6-8.8)克/天。新的研究表明,人类胃肠道中存在钙的味觉受体,信号可能与食欲调节有关。新的证据表明,在能量限制减肥计划期间摄入不足的钙可能会引发饥饿感,并损害对饮食的依从性。这些机制可能部分解释了乳制品对肥胖和代谢综合征的保护作用。