Burden Neurological Institute, Bristol, UK.
J Neurol Sci. 2010 Apr 15;291(1-2):1-4. doi: 10.1016/j.jns.2010.01.017. Epub 2010 Feb 12.
Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability and activation and consequently may affect clinical symptoms in neurological conditions characterized by altered motor cortex functions. There are conflicting reports whether low-frequency rTMS has any clinical effects in Parkinson's disease (PD). Ten patients with PD had rTMS (1800 stimuli at just below active motor threshold intensity) at 1Hz rate delivered over the motor cortex for four consecutive days on two separate occasions. On one of these real rTMS was used and on the other sham rTMS (placebo) was used. Evaluations with UPDRS Part 3 (Motor Scale) were done in practically defined off-phase at the baseline and one day after the end of each of the treatment series. Neither total Motor Scale scores nor subscores for axial symptoms, rigidity, bradykinesia, and tremor showed any significant difference. The results do not confirm presence of residual beneficial clinical after-effects of consecutive daily applications of low-frequency rTMS on motor symptoms in PD, at least when 1800 stimuli at subthreshold intensity are applied for four days.
重复经颅磁刺激（rTMS）可以调节皮质兴奋性和激活，从而可能影响以运动皮层功能改变为特征的神经病症的临床症状。低频 rTMS 在帕金森病（PD）中是否具有任何临床效果存在争议。10 名 PD 患者在两次不同的时间接受 rTMS（1800 次刺激，低于活动运动阈值强度），频率为 1Hz，在运动皮层上连续 4 天进行。其中一次使用真实 rTMS，另一次使用假 rTMS（安慰剂）。在基础期和每次治疗系列结束后一天，使用 UPDRS 第 3 部分（运动量表）进行评估。总运动量表评分和轴症状、僵硬、运动迟缓以及震颤的子评分均无明显差异。结果不支持连续应用低频 rTMS 对 PD 运动症状存在残留的有益临床后效应，至少当应用 1800 次低于阈值强度的刺激持续 4 天时是这样。
