新型 iNOS/Akt 抑制剂 Se,Se'-1,4-亚苯基双(1,2-乙二基)双异硒代脲(PBISe)的合成与表征--用于结肠癌。
Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.
机构信息
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
出版信息
Bioorg Med Chem Lett. 2010 Mar 15;20(6):2038-43. doi: 10.1016/j.bmcl.2009.09.071. Epub 2009 Sep 22.
Abstract
Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.
摘要
我们的研究表明，在已知的 iNOS 抑制剂中用硒取代硫，可以使该化合物在多种不同的癌细胞系中提高几倍的效力。因此，这种方法可以用作提高抗癌药物疗效的策略。
相似文献
1
Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.新型 iNOS/Akt 抑制剂 Se,Se'-1,4-亚苯基双(1,2-乙二基)双异硒代脲(PBISe)的合成与表征--用于结肠癌。
Bioorg Med Chem Lett. 2010 Mar 15;20(6):2038-43. doi: 10.1016/j.bmcl.2009.09.071. Epub 2009 Sep 22.
2
PBISe, a novel selenium-containing drug for the treatment of malignant melanoma.PBISe，一种用于治疗恶性黑色素瘤的新型含硒药物。
Mol Cancer Ther. 2008 May;7(5):1297-308. doi: 10.1158/1535-7163.MCT-07-2267.
3
The selenium analog of the chemopreventive compound S,S'-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer.化学预防化合物S,S'-(1,4-亚苯基双[1,2-乙二基])双异硫脲的硒类似物是人类非小细胞肺癌中一种显著的细胞凋亡诱导剂和细胞生长抑制剂。
Chem Biol Interact. 2009 Jul 15;180(2):158-64. doi: 10.1016/j.cbi.2009.03.003. Epub 2009 Mar 20.
4
Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors.硫脲和硒脲衍生物的简便一锅法合成：一类新型强效脲酶抑制剂
Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91. doi: 10.1016/j.bmcl.2007.07.085. Epub 2007 Aug 22.
5
Melanoma prevention using topical PBISe.使用局部 PBISe 预防黑色素瘤。
Cancer Prev Res (Phila). 2011 Jun;4(6):935-48. doi: 10.1158/1940-6207.CAPR-10-0202. Epub 2011 Mar 2.
6
Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines.对多种癌细胞系具有强大体外活性的新型硒脲和硫脲衍生物。
Eur J Med Chem. 2016 May 4;113:134-44. doi: 10.1016/j.ejmech.2016.02.042. Epub 2016 Feb 18.
7
Chemopreventive effects of PBI-Se, a selenium-containing analog of PBIT, on AOM-induced aberrant crypt foci in F344 rats.PBI-Se（一种含硒 PBIT 类似物）对 AOM 诱导的 F344 大鼠结肠异常隐窝病灶的化学预防作用。
Oncol Rep. 2013 Aug;30(2):952-60. doi: 10.3892/or.2013.2483. Epub 2013 May 23.
8
Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor.诱导型一氧化氮合酶选择性抑制剂对结肠异常隐窝病灶的化学预防作用
Carcinogenesis. 1999 Apr;20(4):641-4. doi: 10.1093/carcin/20.4.641.
9
A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer.一种用于治疗肝细胞癌的含硒抑制剂。
Pharmaceuticals (Basel). 2016 Mar 24;9(2):18. doi: 10.3390/ph9020018.
引用本文的文献
1
A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer.一种用于治疗肝细胞癌的含硒抑制剂。
Pharmaceuticals (Basel). 2016 Mar 24;9(2):18. doi: 10.3390/ph9020018.
2
Microwave-assisted synthesis of new selenazole derivatives with antiproliferative activity.微波辅助合成具有抗增殖活性的新型硒唑衍生物。
Molecules. 2013 Apr 19;18(4):4679-88. doi: 10.3390/molecules18044679.
3
Chemoprevention of melanoma.黑色素瘤的化学预防
Adv Pharmacol. 2012;65:361-98. doi: 10.1016/B978-0-12-397927-8.00012-9.
4
The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.Akt 信号通路：恶性黑色素瘤治疗的新靶点
Cancer Biol Ther. 2011 Dec 15;12(12):1032-49. doi: 10.4161/cbt.12.12.18442.
5
Melanoma prevention using topical PBISe.使用局部 PBISe 预防黑色素瘤。
Cancer Prev Res (Phila). 2011 Jun;4(6):935-48. doi: 10.1158/1940-6207.CAPR-10-0202. Epub 2011 Mar 2.
6
Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib.塞来昔布硒衍生物的合成及抗炎性能评价。
Chem Biol Interact. 2010 Dec 5;188(3):446-56. doi: 10.1016/j.cbi.2010.09.021. Epub 2010 Sep 29.
7
OGA inhibition by GlcNAc-selenazoline.GlcNAc-硒唑啉抑制 OGA。
Bioorg Med Chem. 2010 Oct 1;18(19):7058-64. doi: 10.1016/j.bmc.2010.08.010. Epub 2010 Aug 11.
8
Electrophilic aromatic selenylation: new OPRT inhibitors.亲电芳香硒化反应：新型 OPRT 抑制剂。
Org Lett. 2010 Jul 2;12(13):2982-5. doi: 10.1021/ol1010032.
本文引用的文献
1
The nutritional prevention of cancer: 400 mcg per day selenium treatment.癌症的营养预防：每日400微克硒治疗。
Nutr Cancer. 2008;60(2):155-63. doi: 10.1080/01635580701684856.
2
Plasma selenium measurements in subjects from areas with contrasting gastric cancer risks in Colombia.对哥伦比亚胃癌风险不同地区的受试者进行血浆硒测量。
Arch Med Res. 2008 May;39(4):443-51. doi: 10.1016/j.arcmed.2007.12.004. Epub 2008 Mar 10.
3
Current and future clinical strategies in colon cancer prevention and the emerging role of chemoprevention.结肠癌预防的当前及未来临床策略与化学预防的新作用
Curr Pharm Des. 2007;13(22):2274-82. doi: 10.2174/138161207781368783.
4
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.十字花科蔬菜与人类癌症风险：流行病学证据及作用机制
Pharmacol Res. 2007 Mar;55(3):224-36. doi: 10.1016/j.phrs.2007.01.009. Epub 2007 Jan 25.
5
Selenium: from cancer prevention to DNA damage.硒：从癌症预防到DNA损伤
Toxicology. 2006 Oct 3;227(1-2):1-14. doi: 10.1016/j.tox.2006.07.017. Epub 2006 Jul 25.
6
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells.阐明硒使前列腺癌细胞中Akt失活的机制。
Mol Cancer Ther. 2006 Feb;5(2):246-52. doi: 10.1158/1535-7163.MCT-05-0376.
7
Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds.大蒜及含硫和硒的大蒜化合物对癌症的化学预防作用。
J Nutr. 2006 Mar;136(3 Suppl):864S-869S. doi: 10.1093/jn/136.3.864S.
8
Selenium in cancer prevention: a review of the evidence and mechanism of action.硒在癌症预防中的作用：证据及作用机制综述
Proc Nutr Soc. 2005 Nov;64(4):527-42. doi: 10.1079/pns2005467.
9
Selenium derivatives as cancer preventive agents.
Curr Med Chem Anticancer Agents. 2005 Nov;5(6):637-52. doi: 10.2174/156801105774574676.
10
Perturbations of the AKT signaling pathway in human cancer.人类癌症中AKT信号通路的扰动。
Oncogene. 2005 Nov 14;24(50):7455-64. doi: 10.1038/sj.onc.1209085.
Zotero 插件