新型 iNOS/Akt 抑制剂 Se,Se'-1,4-亚苯基双(1,2-乙二基)双异硒代脲(PBISe)的合成与表征--用于结肠癌。
Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.
机构信息
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
出版信息
Bioorg Med Chem Lett. 2010 Mar 15;20(6):2038-43. doi: 10.1016/j.bmcl.2009.09.071. Epub 2009 Sep 22.
Abstract
Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.
摘要
我们的研究表明，在已知的 iNOS 抑制剂中用硒取代硫，可以使该化合物在多种不同的癌细胞系中提高几倍的效力。因此，这种方法可以用作提高抗癌药物疗效的策略。
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