Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA.
Gynecol Oncol. 2010 May;117(2):341-7. doi: 10.1016/j.ygyno.2010.01.021. Epub 2010 Feb 13.
With the exception of the laying hen, no other animal model of spontaneous ovarian surface epithelial cancer replicates the human disease. Flaxseed is the richest vegetable source of omega-3 fatty acids, which are chemopreventive in breast cancer and may be important in other cancers. The objective of this study was to determine if a flaxseed-enriched diet had a chemopreventive effect on ovarian cancer in the laying hen.
White Leghorn hens were fed with 10% flaxseed-enriched or standard diet for 1 year. The incidence and severity of ovarian cancer were determined by gross pathology and histology in the two groups. General health markers were also measured. Eggs were collected and analyzed by gas chromatography to determine omega-3 fatty acid levels.
A significant reduction in late stage ovarian tumors was detected in the flaxseed-fed hens. Incidence rates of ovarian cancer were not significantly different between the two groups. The results indicate that a flaxseed diet increases overall survival in the laying hen. Flaxseed-fed hens' eggs incorporated significantly more omega-3 fatty acids compared to control hens.
These findings show that 10% flaxseed supplementation for 1 year in the laying hen results in a significant reduction in the severity of ovarian cancer, but no change in the incidence of the disease. Hens fed flaxseed had overall better health and reduced mortality. These findings may provide the basis for a clinical trial that evaluates the efficacy of flaxseed as a chemosuppressant of ovarian cancer in women.
除了蛋鸡以外，没有其他动物模型能够复制自发性卵巢表面上皮癌。亚麻籽是 ω-3 脂肪酸最丰富的植物来源，在乳腺癌中具有化学预防作用，在其他癌症中可能也很重要。本研究的目的是确定富含亚麻籽的饮食是否对蛋鸡的卵巢癌具有化学预防作用。
将白来亨母鸡用 10%富含亚麻籽或标准饮食喂养 1 年。通过两组的大体病理学和组织学来确定卵巢癌的发生率和严重程度。还测量了一般健康指标。收集鸡蛋并通过气相色谱法分析以确定 ω-3 脂肪酸水平。
在喂食亚麻籽的母鸡中，晚期卵巢肿瘤的发生率显著降低。两组之间的卵巢癌发病率没有显著差异。结果表明，亚麻籽饮食可增加蛋鸡的总存活率。与对照组母鸡相比，喂食亚麻籽母鸡的鸡蛋中 incorporated 了更多的 ω-3 脂肪酸。
这些发现表明，在蛋鸡中补充 10%的亚麻籽 1 年可显著降低卵巢癌的严重程度，但对疾病的发病率没有影响。喂食亚麻籽的母鸡总体上健康状况更好，死亡率更低。这些发现可能为评估亚麻籽作为女性卵巢癌化学抑制剂的临床试验提供依据。
