卵巢癌的临床前模型：发病机制、问题及预防意义
Preclinical Models of Ovarian Cancer: Pathogenesis, Problems, and Implications for Prevention.
作者信息
Karnezis Anthony N, Cho Kathleen R
机构信息
*Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada †Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan.
出版信息
Clin Obstet Gynecol. 2017 Dec;60(4):789-800. doi: 10.1097/GRF.0000000000000312.
Abstract
Preclinical models are relatively underutilized and underfunded resources for modeling the pathogenesis and prevention of ovarian cancers. Several reviews have detailed the numerous published models of ovarian cancer. In this review, we will provide an overview of experimental model systems, their strengths and limitations, and use selected models to illustrate how they can be used to address specific issues about ovarian cancer pathogenesis. We will then highlight some of the preclinical prevention studies performed to date and discuss experiments needed to address important unanswered questions about ovarian cancer prevention strategies.
摘要
临床前模型在模拟卵巢癌发病机制和预防方面是相对未得到充分利用和资金投入不足的资源。已有几篇综述详细介绍了众多已发表的卵巢癌模型。在本综述中，我们将概述实验模型系统、它们的优势和局限性，并通过选定的模型来说明如何利用它们来解决有关卵巢癌发病机制的特定问题。然后，我们将重点介绍迄今为止进行的一些临床前预防研究，并讨论为解决有关卵巢癌预防策略的重要未决问题而需要开展的实验。
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