Barua Animesh, Bitterman Pincas, Abramowicz Jacques S, Dirks Angela L, Bahr Janice M, Hales Dale B, Bradaric Michael J, Edassery Seby L, Rotmensch Jacob, Luborsky Judith L
Department of Pharmacology, Rush University Medical Center, Chicago, IL 60612, USA.
Int J Gynecol Cancer. 2009 May;19(4):531-9. doi: 10.1111/IGC.0b013e3181a41613.
The high mortality rate due to ovarian cancer (OVCA) is attributed to the lack of an effective early detection method. Because of the nonspecificity of symptoms at early stage, most of the OVCA cases are detected at late stages. This makes the access to women with early-stage disease problematic and presents a barrier to development and validation of tests for detection of early stage of OVCA in humans. Animal models are used to elucidate disease etiologies and pathogenesis that are difficult to study in humans. Laying hen is the only available animal that develops OVCA spontaneously; however, detailed information on ovarian tumor histology is not available. The goal of this study was to determine the histological features of malignant ovarian tumors in laying hens. A total of 155 young and old (1-5 years of age) laying hens (Gallus domesticus) were selected randomly and evaluated grossly and microscopically for the presence of ovarian tumors. Histological classification of tumors with their stages and grades was determined with reference to those for humans. Similar to humans, all 4 types including serous, endometrioid, mucinous, and clear cell or mixed carcinomas were observed in hen ovarian tumors. Some early neoplastic as well as putative ovarian lesions were also observed. Similarities in histology, metastasis, and stages of hen OVCA to those of humans demonstrate the feasibility of the hen model for additional delineation of the mechanism underlying ovarian carcinogenesis, preclinical testing of new agents for the prevention, and therapy of this disease.
卵巢癌（OVCA）导致的高死亡率归因于缺乏有效的早期检测方法。由于早期症状的非特异性，大多数卵巢癌病例在晚期才被发现。这使得接触患有早期疾病的女性存在问题，并为人类卵巢癌早期检测测试的开发和验证带来了障碍。动物模型用于阐明在人类中难以研究的疾病病因和发病机制。产蛋母鸡是唯一能自发发生卵巢癌的可用动物；然而，关于卵巢肿瘤组织学的详细信息并不存在。本研究的目的是确定产蛋母鸡恶性卵巢肿瘤的组织学特征。总共随机选择了155只年轻和年老（1至5岁）的产蛋母鸡（家鸡），并对其进行大体和显微镜检查以确定是否存在卵巢肿瘤。根据人类肿瘤的分期和分级对肿瘤进行组织学分类。与人类相似，在母鸡卵巢肿瘤中观察到了包括浆液性、子宫内膜样、黏液性和透明细胞或混合性癌在内的所有4种类型。还观察到了一些早期肿瘤以及假定的卵巢病变。母鸡卵巢癌在组织学、转移和分期方面与人类的相似性表明，母鸡模型对于进一步阐明卵巢癌发生机制、预防新药物的临床前测试以及该疾病的治疗具有可行性。
