Division of Pediatric Gastroenterology, Emory University, Atlanta, GA, USA.
Transplant Rev (Orlando). 2010 Apr;24(2):99-103. doi: 10.1016/j.trre.2010.01.003. Epub 2010 Feb 13.
In spite of advances in lung transplantation, the median survival after lung transplant remains less than 5 years, an outcome that is significantly worse than other solid organ transplants. Efforts to understand the unique hurdles faced in lung transplant have revealed gastroesophageal reflux disease (GERD) as a risk factor for ultimate graft failure. The link between GERD and chronic lung rejection parallels the association between GERD and other forms of lung disease such as idiopathic pulmonary fibrosis. Understanding how GERD predisposes to graft failure is an important issue as it may lead to therapies such as surgical correction that aim to lessen the exposure of the pulmonary epithelium to gastric contents. Here, we review the link between GERD and lung disease and discuss the preclinical and clinical studies that are starting to elucidate a mechanism for this association.
尽管肺移植技术取得了进展，但肺移植后的中位生存期仍不到 5 年，这一结果明显劣于其他实体器官移植。为了了解肺移植所面临的独特障碍，研究发现胃食管反流病（GERD）是导致移植物最终衰竭的一个危险因素。GERD 与慢性肺排斥之间的联系类似于 GERD 与特发性肺纤维化等其他形式的肺部疾病之间的关联。了解 GERD 如何导致移植物衰竭是一个重要问题，因为它可能导致旨在减少肺上皮暴露于胃内容物的治疗方法，如手术矫正。在这里，我们回顾了 GERD 与肺部疾病之间的联系，并讨论了开始阐明这种关联机制的临床前和临床研究。
