Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(2):117-30. doi: 10.2183/pjab.86.117.
Molecular biology of mouse and chicken retroviruses had identified oncogenes and provided a revolutionary concept in understanding of cancers. A human retrovirus was established during 1980-1982 in linkage with a unique human leukemia, concurrently in Japan and USA. This review covers our efforts on the discovery of new retrovirus, Human T-cell Leukemia Virus Type 1 (HTLV-1), first introducing to a new class of retroviruses with a unique regulatory factors, Tax and Rex. Then it is followed by analyses of molecular interaction of the vial Tax with cellular machineries involved in the pathogenesis of Adult T-cell Leukemia (ATL). And then a probable mechanism of pathogenesis of ATL is proposed including recent findings on HBZ after our efforts.
鼠和鸡逆转录病毒的分子生物学已经确定了癌基因,并为理解癌症提供了革命性的概念。一种人类逆转录病毒于 1980-1982 年在与独特的人类白血病相关联的情况下,在日本和美国同时被建立。这篇综述涵盖了我们在发现新的逆转录病毒,人类 T 细胞白血病病毒 1 型(HTLV-1)方面的努力,首先引入了一类具有独特调节因子 Tax 和 Rex 的新型逆转录病毒。然后,分析了病毒 Tax 与参与成人 T 细胞白血病(ATL)发病机制的细胞机制之间的分子相互作用。然后提出了 ATL 发病机制的可能机制,包括我们努力后的 HBZ 的最新发现。