第一种人类逆转录病毒的发现：人类嗜T淋巴细胞病毒1型（HTLV-1）和人类嗜T淋巴细胞病毒2型（HTLV-2）。
The discovery of the first human retrovirus: HTLV-1 and HTLV-2.
作者信息
Gallo Robert C
机构信息
Institute of Human Virology University of Maryland Biotechnology Institute 701 E, Pratt Street Baltimore, MD 21202, USA.
出版信息
Retrovirology. 2005 Mar 2;2:17. doi: 10.1186/1742-4690-2-17.
Abstract
I describe here the history leading up to and including my laboratory's discovery of the first human retrovirus, HTLV-I, and its close relative, HTLV-II. My efforts were inspired by early work showing a retroviral etiology for leukemias in various animals, including non-human primates. My two main approaches were to develop criteria for and methods for detection of viral reverse transcriptase and to identify growth factors that could support the growth of hematopoietic cells. These efforts finally yielded success following the discovery of IL-2 and its use to culture adult T cell lymphoma/leukemia cells.
摘要
在此，我将讲述我的实验室发现首例人类逆转录病毒HTLV - I及其近亲HTLV - II之前的历史，包括这一发现过程本身。早期有研究表明包括非人灵长类动物在内的多种动物的白血病存在逆转录病毒病因，这激发了我的研究工作。我的两个主要方法是制定检测病毒逆转录酶的标准和方法，以及识别能够支持造血细胞生长的生长因子。在发现白细胞介素 - 2并将其用于培养成人T细胞淋巴瘤/白血病细胞之后，这些努力最终取得了成功。
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