Group Health Research Institute, 1730 Minor Avenue Suite 1600, Seattle, WA, 98101, USA.
Cancer Causes Control. 2010 Jun;21(6):863-70. doi: 10.1007/s10552-010-9513-x. Epub 2010 Feb 13.
Little is known about the relationship between alcohol intake and breast cancer risk among Mexican women. This association may be modified by folate and Vitamin B12.
A population-based case-control study conducted in Mexico recruited 1,000 incident breast cancer cases aged 35-69 and 1,074 controls matched on age, region, and health care system. In-person interviews were conducted to assess breast cancer risk factors and recent diet using a food frequency questionnaire. Conditional logistic regression models estimated adjusted odds ratios and 95% confidence intervals.
Over one-half (57%) of cases and less than one-half of controls (45%) reported any lifetime alcohol consumption. Compared with never drinkers, women reporting ever drinking (Adjusted OR = 1.25, 95% CI = 0.99-1.58) had a greater odds of breast cancer. There was evidence for interaction in the association between ever consuming any alcohol and breast cancer by folate (p for interaction = 0.04) suggesting women with lower folate intake had a higher odds of breast cancer (Adjusted OR = 1.99, 95% CI = 1.26-3.16) compared to women with higher folate intake (OR = 1.12, 95% CI = 0.69-1.83).
Our findings support evidence that any alcohol intake increases risk of breast cancer. Insufficient intake of folate may further elevate risk for developing breast cancer among women who consume alcohol.
墨西哥女性的饮酒量与乳腺癌风险之间的关系知之甚少。这种关联可能会受到叶酸和维生素 B12 的影响。
这项在墨西哥开展的基于人群的病例对照研究纳入了 1000 名年龄在 35-69 岁之间的新发乳腺癌病例和 1074 名按年龄、地区和医疗保健系统匹配的对照。通过食物频率问卷，对乳腺癌风险因素和近期饮食进行了面对面访谈。使用条件逻辑回归模型，估计了调整后的比值比和 95%置信区间。
超过一半（57%）的病例和不到一半（45%）的对照报告有任何终身饮酒。与从不饮酒者相比，报告曾经饮酒的女性（调整后的比值比=1.25，95%CI=0.99-1.58）乳腺癌的发病几率更高。在叶酸摄入量方面，存在饮酒与乳腺癌之间关联的交互作用（p 值=0.04），这表明叶酸摄入量较低的女性乳腺癌发病几率更高（调整后的比值比=1.99，95%CI=1.26-3.16），而叶酸摄入量较高的女性乳腺癌发病几率较低（比值比=1.12，95%CI=0.69-1.83）。
我们的研究结果支持了饮酒会增加乳腺癌风险的证据。叶酸摄入不足可能会进一步增加饮酒女性患乳腺癌的风险。
