Australian Quarantine and Inspection Service, Canberra City, ACT 2601, Australia.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Mar;27(3):302-14. doi: 10.1080/19440040903296683.
Physiologically based pharmacokinetic (PBPK) modelling has been used to examine the relative importance of physiological differences between laying hens and broiler chickens as well as between broiler chickens and ducks, geese, and turkeys in determining tissue residues. Following exposure in feed, there may be significant differences in tissue residues between laying hens and broiler chickens. The blood lipid content of laying versus broilers, the duration of exposure, and the fraction of the dose absorbed into the systemic circulation were important parameters together with tissue-to-blood partition coefficients. The potential for modelling to improve the extrapolation of residue transfer studies carried out using laying hens to broiler chickens and other poultry is demonstrated.
生理药代动力学（PBPK）模型已被用于研究蛋鸡和肉鸡之间、肉鸡和鸭、鹅、火鸡之间的生理差异在确定组织残留中的相对重要性。在饲料中暴露后，蛋鸡和肉鸡之间的组织残留可能存在显著差异。与肉鸡相比，蛋鸡的血液脂质含量、暴露时间以及进入体循环的剂量分数是重要参数，还有组织与血液的分配系数。该模型具有改善使用蛋鸡进行的残留转移研究外推到肉鸡和其他家禽的潜力。
