Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610-0236, USA.
J Clin Exp Neuropsychol. 2010 Aug;32(7):673-81. doi: 10.1080/13803390903427406. Epub 2010 Feb 10.
White matter changes are one potential etiology of behavioral changes in cerebrovascular disease. Whole brain diffusion tensor imaging-fractional anisotropy (DTI-FA) as a measure of apparent white matter integrity is related to cognitive function in cerebrovascular disease. However, white matter changes are not uniform, nor are their effects. We examine the relationship between regional differences in DTI-FA and cognition and mood in an ischemic-stroke sample. Participants were 108 patients, 3-6 months post stroke. Working memory, basic attention, recall, language, visuo-spatial, psychomotor, and encoding skills, and mood were assessed via neuropsychological evaluation. DTI scans were performed on a 1.5 T GE magnetic resonance imaging (MRI) system. Fractional anisotropy (FA) was calculated for frontal, temporal, occipital, and parietal regions using automated masks. Frontal and parietal FAs were more strongly and consistently related to cognitive and mood scores than were FA values from whole brain or temporal or occipital regions. This research contributes to our understanding of the etiology of cognitive and mood deficits in cerebrovascular disease.
脑白质变化是脑血管病行为改变的一个潜在病因。全脑弥散张量成像-各向异性分数（DTI-FA）作为一种表观白质完整性的测量方法，与脑血管病的认知功能有关。然而，白质变化并不均匀，其影响也不相同。我们在缺血性中风样本中检查了 DTI-FA 与认知和情绪之间的区域差异关系。参与者为 108 名中风后 3-6 个月的患者。通过神经心理学评估评估了工作记忆、基本注意力、回忆、语言、视空间、精神运动和编码技能以及情绪。DTI 扫描在 1.5 T GE 磁共振成像（MRI）系统上进行。使用自动掩模计算额、颞、顶和枕叶区域的各向异性分数（FA）。额叶和顶叶的 FA 与认知和情绪评分的关系比全脑或颞叶或枕叶的 FA 值更强烈和更一致。这项研究有助于我们理解脑血管病认知和情绪缺陷的病因。
