从软珊瑚 Sinularia capillosa 中分离得到的抗病毒和抗炎代谢产物。

Antiviral and anti-inflammatory metabolites from the soft coral Sinularia capillosa.

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.

出版信息

J Nat Prod. 2010 Apr 23;73(4):771-5. doi: 10.1021/np9008078.

DOI:10.1021/np9008078

PMID:20155971

Abstract

Chemical investigations of the soft coral Sinularia capillosa resulted in the isolation of one new tetraprenylbenzoquinone, capilloquinone (1), two new furanobenzosesquiterpenoids, capillobenzopyranol (2) and capillobenzofuranol (3), one new furanosesquiterpenoid, capillofuranocarboxylate (4), and five previously characterized metabolites, comprising (E)-5-(2,6-dimethylocta-5,7-dienyl)furan-3-carboxylic acid (5), 2-[(2E,6E)-3,7-dimethyl-8-(4-methylfuran-2-yl)octa-2,6-dienyl]-5-methylcyclohexa-2,5-diene-1,4-dione (6), 2-[(2E,6E)-3,7-dimethyl-8-(4-methylfuran-2-yl)octa-2,6-dienyl]-5-methylbenzene-1,4-diol (7), (-)-loliolide (8), and 3,4,11-trimethyl-7-methylenebicyclo[6.3.0]undec-2-en-11alpha-ol (9). The structures of 1-4 were elucidated through extensive spectroscopic analysis. The cytotoxicity, anti-HCMV (human cytomegalovirus) activity, antibacterial activity, and anti-inflammatory effects of 1-9 were evaluated in vitro.

摘要

从软珊瑚 Sinularia capillosa 中提取的化学成分研究结果分离得到一个新的四萜烯苯醌，即 capilloquinone (1)，两个新的呋喃苯并倍半萜，capillobenzopyranol (2) 和 capillobenzofuranol (3)，一个新的呋喃倍半萜，capillofuranocarboxylate (4)，以及五个以前表征的代谢物，包括 (E)-5-(2,6-二甲基辛-5,7-二烯基)呋喃-3-羧酸 (5)，2-[(2E,6E)-3,7-二甲基-8-(4-甲基呋喃-2-基)辛-2,6-二烯基]-5-甲基环己-2,5-二烯-1,4-二酮 (6)，2-[(2E,6E)-3,7-二甲基-8-(4-甲基呋喃-2-基)辛-2,6-二烯基]-5-甲基苯-1,4-二醇 (7)，(-)-loliolide (8)，和 3,4,11-三甲基-7-亚甲基双环[6.3.0]十一-2-烯-11α-醇 (9)。通过广泛的光谱分析阐明了 1-4 的结构。在体外评估了 1-9 的细胞毒性、抗 HCMV（人巨细胞病毒）活性、抗菌活性和抗炎作用。