来自台湾软珊瑚覆瓦短指软珊瑚的卡普内内酯。

Capnellenes from the Formosan soft coral Capnella imbricata.

作者信息

Chang Chin-Hsiang, Wen Zhi-Hong, Wang Shang-Kwei, Duh Chang-Yih

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

出版信息

J Nat Prod. 2008 Apr;71(4):619-21. doi: 10.1021/np0706116. Epub 2008 Feb 27.

DOI:10.1021/np0706116

PMID:18302334

Abstract

Three anti-inflammatory sesquiterpenes, Delta (9(12))-capnellene-8beta,10alpha-diol ( 1), 8alpha-acetoxy-Delta (9(12))-capnellene-10alpha-ol ( 2), and Delta (9(12))-capnellene-10alpha-ol-8-one ( 3), five new sesquiterpenes, Delta (9(12))-capnellene-8beta,15-diol ( 4), Delta (9(12))-capnellene-8beta,10alpha,13-triol ( 5), Delta (9(10))-capnellene-12-ol-8-one ( 6), 8beta,10alpha-diacetoxy-Delta (9(12))-capnellene ( 7), and 8beta-acetoxy-Delta (9(12))-capnellene ( 8), and a known sesquiterpene, Delta (9(12))-capnellene-8beta-ol ( 9), were isolated from the acetone/methylene chloride extracts of the Formosan soft coral Capnella imbricata. The structures of these compounds were elucidated by extensive spectroscopic analysis.

摘要

从台湾软珊瑚交织拟杯螅的丙酮/二氯甲烷提取物中分离出三种抗炎倍半萜，Δ(9(12))-蒈二烯-8β,10α-二醇(1)、8α-乙酰氧基-Δ(9(12))-蒈二烯-10α-醇(2)和Δ(9(12))-蒈二烯-10α-醇-8-酮(3)，五种新的倍半萜，Δ(9(12))-蒈二烯-8β,15-二醇(4)、Δ(9(12))-蒈二烯-8β,10α,13-三醇(5)、Δ(9(10))-蒈二烯-12-醇-8-酮(6)、8β,10α-二乙酰氧基-Δ(9(12))-蒈二烯(7)和8β-乙酰氧基-Δ(9(12))-蒈二烯(8)，以及一种已知的倍半萜，Δ(9(12))-蒈二烯-8β-醇(9)。通过广泛的光谱分析阐明了这些化合物的结构。