来自台湾软珊瑚光滑软柳珊瑚的倍半萜类化合物和去甲倍半萜类化合物。

Sesquiterpenoids and norsesquiterpenoids from the Formosan soft coral Lemnalia laevis.

作者信息

El-Gamal Ali A H, Chiu E-Ping, Li Chia-Hua, Cheng Shi-Yie, Dai Chang-Feng, Duh Chang-Yih

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

出版信息

J Nat Prod. 2005 Dec;68(12):1749-53. doi: 10.1021/np050326r.

DOI:10.1021/np050326r

PMID:16378367

Abstract

Eight new nornardosinane sequiterpenoids, laevinols A-H (1-8), a new neolemnane sesquiterpenoid, laevinone A (9), and the previously known 6beta-acetyl-4beta,5beta-dimethyl-1(10)alpha-epoxy-2beta-hydroxy-7-oxodecalin (10) and 11,12-dihydroxy-6,10-eremophiladiene (11) were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia laevis. Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

摘要

从台湾软珊瑚平滑软柳珊瑚（Lemnalia laevis）的二氯甲烷可溶部分中分离出8个新的降香橙烷倍半萜类化合物，左旋醇A - H（1 - 8），1个新的新海松烷倍半萜类化合物，左旋酮A（9），以及之前已知的6β - 乙酰基 - 4β，5β - 二甲基 - 1(10)α - 环氧 - 2β - 羟基 - 7 - 氧代十氢化萘（10）和11,12 - 二羟基 - 6,10 - 艾里莫芬二烯（11）。通过广泛的光谱分析阐明了它们的结构，并在体外测定了它们对所选癌细胞的细胞毒性。