Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 S University Ave, Philadelphia, PA 19104, United States.
J Neuroimmunol. 2010 May;222(1-2):19-28. doi: 10.1016/j.jneuroim.2009.12.009. Epub 2010 Feb 13.
In this study, the role of NF-kappaB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-kappaB1(-/-) mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8(+) T cells and IFN-gamma production, while accessory cell function appeared intact in NF-kappaB1(-/-) mice. Consistent with these findings, T cell transfer studies revealed that NF-kappaB1(-/-) T cells provided SCID mice less protection than wildtype T cells. These results demonstrate an intrinsic role for NF-kappaB1 in T cell-mediated immunity to Toxoplasmagondii.
在这项研究中，研究了 NF-κB1 在弓形虫病中的作用。虽然野生型 BALB/c 小鼠产生了保护性反应，但 NF-κB1（-/-）小鼠发展为弓形虫脑炎，其特征是脑内寄生虫负荷增加和坏死。易感性主要与 CD8（+）T 细胞数量和 IFN-γ产生的局部减少有关，而辅助细胞功能在 NF-κB1（-/-）小鼠中似乎完整。与这些发现一致，T 细胞转移研究表明，NF-κB1（-/-）T 细胞比野生型 T 细胞为 SCID 小鼠提供的保护作用更小。这些结果表明 NF-κB1 在 T 细胞介导的弓形虫免疫中具有内在作用。
