School of Medicine, University of Tasmania, Hobart, Tasmania, 7001, Australia.
J Cyst Fibros. 2010 May;9(3):158-64. doi: 10.1016/j.jcf.2009.12.003. Epub 2010 Feb 13.
Two recent studies have demonstrated the presence of biologically significant amounts of cyanide within the airways of cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa. Whilst environmental strains of P. aeruginosa are known to synthesise cyanide, there has been a relative lack of investigation into bacterial cyanogenesis from a medical viewpoint, despite the role P. aeruginosa plays in many serious infection settings and especially in CF lung disease. This review discusses the implications of cyanogenesis in the CF airway in terms of bacterial ecology, host immune response, progression of lung disease and potential treatment options.
两篇最近的研究表明，囊性纤维化（CF）患者气道中存在具有生物学意义的氰化物，这些患者感染了铜绿假单胞菌。虽然环境中分离出的铜绿假单胞菌已知能够合成氰化物，但从医学角度来看，细菌氰生成的研究相对较少，尽管铜绿假单胞菌在许多严重感染环境中发挥作用，尤其是在 CF 肺部疾病中。本文讨论了 CF 气道中氰生成对细菌生态学、宿主免疫反应、肺部疾病进展以及潜在治疗选择的影响。
