差分式离子淌度谱：代谢疾病的非侵入性实时诊断和治疗控制。

Differential ion mobility spectroscopy: non-invasive real-time diagnostics and therapy control in metabolic diseases.

机构信息

Neptuntec, Grüne Aue 54, 12683 Berlin, Germany.

出版信息

Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):121-5. doi: 10.1186/2047-783x-14-s4-121.

DOI:10.1186/2047-783x-14-s4-121

PMID:20156741

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3521328/

Abstract

BACKGROUND

Over the last few years, differential ion mobility spectroscopy (DMS) has become an important tool in medical research. There are attempts to find markers for specific diseases in exhaled air, using this technology as a non-invasive early diagnosis.

OBJECTIVE

In the present research, exhaled air from 78 patients with known diagnosis and 39 control persons were tested with a DMS system from Sionex.

RESULTS

Bronchial asthma showed a pattern of 6 characteristic points in a discriminant analysis. Patients with diagnosed hypertension showed a characteristic pattern with 4 points, hypothyroidism 2 points; increased LDL cholesterol 3 points, and type II diabetics treated with insulin 4 spots. No significant differences with respect to the control group were found in chronic obstructive pulmonary disease patients. The DMS pattern in the tested asthmatics showed a partial change depending on different medications used.

CONCLUSION

Differential ion mobility spectroscopy offers promise as a helpful diagnostic tool.

摘要

背景

在过去的几年中，差分离子迁移谱（DMS）已成为医学研究中的重要工具。有人试图使用这项技术作为非侵入性的早期诊断方法，在呼出的空气中寻找特定疾病的标志物。

目的

本研究使用 Sionex 的 DMS 系统对 78 名已知诊断的患者和 39 名对照者的呼出空气进行了测试。

结果

支气管哮喘在判别分析中呈现出 6 个特征点的模式。诊断为高血压的患者呈现出 4 个特征点、甲状腺功能减退症呈现出 2 个特征点的特征模式；低密度脂蛋白胆固醇升高 3 点，接受胰岛素治疗的 2 型糖尿病患者 4 点。慢性阻塞性肺疾病患者与对照组相比无显著差异。测试的哮喘患者的 DMS 模式显示，根据使用的不同药物，存在部分变化。