Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, Warsaw, Poland.
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):192-5. doi: 10.1186/2047-783x-14-s4-192.
The paper describes the possible role of apoptosis of T lymphocytes in asthma pathogenesis. The authors focused on resistance against Fas-mediated programed cell death and the role of Bcl-2 protein in impaired programed cell death process. The reports from the literature regarding the imbalance of Th1 and Th2, caused by impaired apoptosis of T cells, in asthma pathogenesis are reviewed.
本文描述了 T 淋巴细胞凋亡在哮喘发病机制中的可能作用。作者关注的是对 Fas 介导的程序性细胞死亡的抵抗力和 Bcl-2 蛋白在受损的程序性细胞死亡过程中的作用。本文综述了有关 T 细胞凋亡受损导致 Th1 和 Th2 失衡在哮喘发病机制中的作用的文献报道。
