Department of Pediatrics and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):196-200. doi: 10.1186/2047-783x-14-s4-196.
The aim of the study was to investigate whether the G-174C polymorphism of the IL-6 gene is related to obesity and the incidence of the metabolic syndrome (MetS) according to IDF definition in children.
The examined group included 124 obese children with BMI > or = 2 SDS, and the control group consisted of 56 non-obese children with BMI <1.0 SDS. Polymorphism identification was performed in total genomic DNA using PCR-RFLP method.
In the obese children, carriers of C allele in homozygotic and heterozygotic genotypes were more frequent than in the control group. The carriers of C alleles presented with lower thickness of subcutaneous tissue and higher concentrations of HDL-C than the wild type. The incidence of MetS was 33% of the group of obese children. Analysis of the presence of MetS factors showed that there is more frequent MetS in the group with the wild homozygous genotype type.
Polymorphism 174G>C in the IL-6 gene does not seem to be associated with obesity and with the incidence of MetS in children.
本研究旨在探讨白细胞介素 6（IL-6）基因 G-174C 多态性是否与肥胖以及根据 IDF 定义的儿童代谢综合征（MetS）的发生有关。
实验组包括 124 名 BMI≥2 SDS 的肥胖儿童，对照组由 56 名 BMI＜1.0 SDS 的非肥胖儿童组成。采用 PCR-RFLP 法检测总基因组 DNA 中的多态性。
在肥胖儿童中，CC 纯合子和杂合子基因型的 C 等位基因携带者比对照组更为常见。C 等位基因携带者的皮下组织厚度较低，HDL-C 浓度较高。肥胖儿童的 MetS 发生率为 33%。对 MetS 因素的存在进行分析表明，野生型纯合子基因型组中 MetS 更为常见。
IL-6 基因 174G>C 多态性似乎与肥胖和儿童 MetS 的发生无关。
