肥胖儿童白细胞介素-6 基因 G-174C 多态性与代谢紊乱的关系。
Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children.
机构信息
Department of Pediatrics and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
出版信息
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):196-200. doi: 10.1186/2047-783x-14-s4-196.
OBJECTIVE
The aim of the study was to investigate whether the G-174C polymorphism of the IL-6 gene is related to obesity and the incidence of the metabolic syndrome (MetS) according to IDF definition in children.
MATERIALS AND METHODS
The examined group included 124 obese children with BMI > or = 2 SDS, and the control group consisted of 56 non-obese children with BMI <1.0 SDS. Polymorphism identification was performed in total genomic DNA using PCR-RFLP method.
RESULTS
In the obese children, carriers of C allele in homozygotic and heterozygotic genotypes were more frequent than in the control group. The carriers of C alleles presented with lower thickness of subcutaneous tissue and higher concentrations of HDL-C than the wild type. The incidence of MetS was 33% of the group of obese children. Analysis of the presence of MetS factors showed that there is more frequent MetS in the group with the wild homozygous genotype type.
CONCLUSION
Polymorphism 174G>C in the IL-6 gene does not seem to be associated with obesity and with the incidence of MetS in children.
目的
本研究旨在探讨白细胞介素 6（IL-6）基因 G-174C 多态性是否与肥胖以及根据 IDF 定义的儿童代谢综合征（MetS）的发生有关。
材料和方法
实验组包括 124 名 BMI≥2 SDS 的肥胖儿童，对照组由 56 名 BMI＜1.0 SDS 的非肥胖儿童组成。采用 PCR-RFLP 法检测总基因组 DNA 中的多态性。
结果
在肥胖儿童中，CC 纯合子和杂合子基因型的 C 等位基因携带者比对照组更为常见。C 等位基因携带者的皮下组织厚度较低，HDL-C 浓度较高。肥胖儿童的 MetS 发生率为 33%。对 MetS 因素的存在进行分析表明，野生型纯合子基因型组中 MetS 更为常见。
结论
IL-6 基因 174G>C 多态性似乎与肥胖和儿童 MetS 的发生无关。
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