Teixeira Andrei Alkmim, Quinto Beata Marie Redublo, Dalboni Maria Aparecida, Rodrigues Cassio Jose de Oliveira, Batista Marcelo Costa
Nephrology Division, EPM, Universidade Federal de São Paulo (UNIFESP), 04039-032 São Paulo, SP, Brazil.
Nephrology Division, EPM, Universidade Federal de São Paulo (UNIFESP), 04039-032 São Paulo, SP, Brazil ; Nove de Julho University, 01156-050 São Paulo, SP, Brazil.
Biomed Res Int. 2015;2015:927589. doi: 10.1155/2015/927589. Epub 2015 Feb 28.
Visceral obesity, the central core of metabolic syndrome (MetS), is conceived as the pathogenic basis of an increased cardiovascular burden and is related with changes in cytokines. We investigated whether IL-6-174G/C gene polymorphism is associated with MetS prevalence in hypertensive patients.
A population of hypertensive patients was included and stratified by the presence of MetS according to IDF criteria and evaluated by Framingham risk score. The IL-6-174G/C genotyping was performed by polymerase chain reaction and the prevalence of MetS was compared between "C" carrier and "non-C" carrier groups.
From an original sample of 664 patients, 612 (34.2% men, age 57.3 ± 10.1, 30.4% diabetics) were included. MetS was diagnosed in 51.3% of total population and "C" carriers demonstrated high prevalence of MetS (P < 0.05) and each of its components. On binary logistic regression, it was observed that the IL-6 polymorphism was independently associated with occurrence of MetS, even after adjusting for covariates (OR 1.13-2.37, 95% CI, P < 0.05).
The C allele at the -174 locus of IL-6 gene is independently associated with the occurrence of metabolic syndrome, emphasizing the importance of inflammatory genetic background in the pathogenesis of visceral obesity and related cardiovascular burden.
内脏肥胖是代谢综合征（MetS）的核心，被认为是心血管负担增加的致病基础，且与细胞因子变化有关。我们研究了白细胞介素-6（IL-6）-174G/C基因多态性是否与高血压患者的MetS患病率相关。
纳入一组高血压患者，根据国际糖尿病联盟（IDF）标准按是否存在MetS进行分层，并通过弗明汉风险评分进行评估。采用聚合酶链反应进行IL-6-174G/C基因分型，比较“C”等位基因携带者和“非C”等位基因携带者组之间的MetS患病率。
从664例患者的原始样本中，纳入了612例（男性占34.2%，年龄57.3±10.1岁，糖尿病患者占30.4%）。在总人口中，51.3%被诊断为MetS，“C”等位基因携带者的MetS及其各组分的患病率均较高（P<0.05）。在二元逻辑回归分析中，发现即使在调整协变量后，IL-6基因多态性仍与MetS的发生独立相关（比值比1.13 - 2.37，95%可信区间，P<0.05）。
IL-6基因-174位点的C等位基因与代谢综合征的发生独立相关，强调了炎症遗传背景在内脏肥胖发病机制及相关心血管负担中的重要性。
