Department of the Prevention of Envirnomental Hazards and Allergology, Warsaw Medical University, Warsaw, Poland.
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):227-32. doi: 10.1186/2047-783x-14-s4-227.
We assessed correlations of total and specific cord-blood IgE (cIgE) levels with allergic symptoms in the first year of life. cIgE levels were determined by an immunoassay test in full-term neonates. This is a prospective study in which a questionnaire was used after birth, and at 6 and 12 months of age. We used multiple logistic regression models to assess the association between the family history of atopy and the incidence of allergy. The infants were divided into groups based on the cIgE level (Group 1<0.1 IU/ml, n=65; Group 2 0.1-0.5 IU/ml, n=63; Group 3 >0.5 IU/ml, n=45). We found the symptoms of atopy in 26 children in Group 1 (40%), 30 (47.6%) in Group 2, and 17 (37.7%) in Group 3; the percentage of atopic diseases was insignificantly different among the three groups. No association between a high total cIgE and specific cIgE with atopy family history and the outcome of atopic diseases was discovered. We conclude that neither total nor specific cIgE level with atopy family history can be used as an indicator to single out high risk infants.
我们评估了脐带血总 IgE（cIgE）和特异性 IgE 水平与生命第一年过敏症状的相关性。通过对足月新生儿进行免疫测定试验来确定 cIgE 水平。这是一项前瞻性研究，在出生后、6 个月和 12 个月时使用问卷进行研究。我们使用多变量逻辑回归模型来评估特应性家族史与过敏发生之间的关联。根据 cIgE 水平将婴儿分为三组（第 1 组<0.1 IU/ml，n=65；第 2 组 0.1-0.5 IU/ml，n=63；第 3 组>0.5 IU/ml，n=45）。我们发现第 1 组 26 名儿童（40%）、第 2 组 30 名儿童（47.6%）和第 3 组 17 名儿童（37.7%）出现特应性症状；三组之间特应性疾病的比例无显著差异。未发现总 cIgE 和特异性 cIgE 与特应性家族史和特应性疾病结局之间存在关联。我们得出结论，特应性家族史时 cIgE 水平无论是总 IgE 还是特异性 IgE 都不能作为识别高风险婴儿的指标。
