Eiríksson T H, Sigurgeirsson B, Ardal B, Sigfússon A, Valdimarsson H
Department of Immunology, National University Hospital, Landspítalinn, Reykjavík, Iceland.
Pediatr Allergy Immunol. 1994 Feb;5(1):5-10. doi: 10.1111/j.1399-3038.1994.tb00211.x.
The predictive value of cord blood IgE (cIgE) for atopy and related disorders was investigated. Samples were collected from 792 infants delivered consecutively at the National University Hospital in Reykjavík in 1987. The concentration of IgE, but not that of IgA, was found to increase with increasing gestational age at birth. There was no correlation between IgE and IgA levels in individual samples. At the age of 18-23 months 180 of these children were studied for manifestations of allergy and related disorders. Included were all available infants with detectable (> or = 0.23 kU/L) cIgE. However, infants born by Cesarean section or with IgA exceeding 10 mg/L were excluded because of potential contamination with maternal blood. The clinical evaluation was made without knowledge of the IgE levels. Sixty-six of the 180 participants (36.6%) were judged to have had definite allergic manifestations. However, no striking correlation was found between allergic symptoms and cIgE levels in this study, nor did high levels of IgE add significantly to the predictive value of family history. Children with atopic features had more frequently been affected by otitis media. Unexpectedly, infants with intermediate cIgE levels (0.2-0.6 kU/L) were significantly less affected by otitis media than children with unmeasurable (< 0.2 kU/L) or high (> or = 0.7 kU/L) cIgE levels. It is concluded that cord blood IgE can not be used to predict allergic manifestations in children under the age of 2 years.
研究了脐血IgE（cIgE）对特应性疾病及相关病症的预测价值。样本取自1987年在雷克雅未克国立大学医院连续分娩的792名婴儿。发现出生时IgE的浓度随胎龄增加而升高，但IgA的浓度并非如此。各个样本中IgE和IgA水平之间无相关性。在18至23个月大时，对其中180名儿童的过敏及相关病症表现进行了研究。纳入了所有可检测到（≥0.23 kU/L）cIgE的婴儿。然而，剖宫产出生或IgA超过10 mg/L的婴儿因可能受母体血液污染而被排除。临床评估在不知IgE水平的情况下进行。180名参与者中有66名（36.6%）被判定有明确的过敏表现。然而，本研究中未发现过敏症状与cIgE水平之间有显著相关性，IgE水平高也未显著增加家族史的预测价值。有特应性特征的儿童患中耳炎的频率更高。出乎意料的是，cIgE水平中等（0.2 - 0.6 kU/L）的婴儿患中耳炎的情况明显少于cIgE水平不可测（<0.2 kU/L）或高（≥0.7 kU/L）的儿童。结论是脐血IgE不能用于预测2岁以下儿童的过敏表现。
