Shah Shilpa, Bapat M M
Institute of Science, 15, Madam Cama Road, Mumbai - 400 003, India.
Indian J Med Sci. 2006 Jan;60(1):13-8.
Allergic reactions are responsible for much illness, irritation and disquiet in the life of the child. Recognition and management of allergy in childhood is of great importance to prevent major allergic syndromes.
To correlate cord serum IgE with parental history of allergy and maternal serum IgE.
In consultation with the attending gynecologist a survey of 950 pregnant women from different parts of Mumbai, visiting gynecology clinics was carried out.
100 pregnant women were randomly recruited for the study. Allergic history of both the parents was collected. Blood samples of mothers and matched cord blood samples were collected. Total serum IgE levels were determined using solid-phase immunoradiometric assay. Total serum IgA from each cord blood sample was checked.
OBSERVATION & RESULTS: (1) Positive correlation was observed between cord serum IgE and matched maternal serum IgE, with mothers having history of allergy. (2) There was no relation (P=0.99) between cord serum IgE and matched maternal serum IgE, where mothers had no history of allergy. (3) A significant elevation in cord serum IgE was found only with maternal but not with paternal history of allergy. (4) No elevation was found in cord serum IgE (0.5 IU/mL). (6) All cord serum samples had IgA< 0.06 IU/mL ruling out the possibility of contamination with maternal blood.
The maternal history of allergic disease is associated with an elevated cord serum IgE among newborns. Cord serum IgE is a simple, non-invasive and convenient test, which can supplement the maternal history to provide more discriminative information about the allergic status of the newborn.
过敏反应在儿童生活中引发了诸多疾病、不适与困扰。认识并管理儿童过敏对于预防重大过敏综合征至关重要。
将脐血血清免疫球蛋白E（IgE）与父母过敏史及母亲血清IgE进行关联研究。
与主治妇科医生协商后，对孟买不同地区前往妇科诊所就诊的950名孕妇进行了一项调查。
随机招募100名孕妇参与研究。收集父母双方的过敏史。采集母亲的血样及配对的脐血样本。采用固相免疫放射分析法定量测定血清总IgE水平。检测每份脐血样本中的血清总IgA。
（1）在有过敏史的母亲中，观察到脐血血清IgE与配对的母亲血清IgE呈正相关。（2）在无过敏史的母亲中，脐血血清IgE与配对的母亲血清IgE之间无关联（P = 0.99）。（3）仅在母亲有过敏史而非父亲有过敏史时，脐血血清IgE显著升高。（4）脐血血清IgE未升高（<0.5 IU/mL）。（6）所有脐血样本的IgA<0.06 IU/mL，排除了母血污染的可能性。
母亲的过敏性疾病史与新生儿脐血血清IgE升高有关。脐血血清IgE检测是一项简单、无创且便捷的检查，可补充母亲的病史信息，为新生儿的过敏状态提供更具鉴别性的信息。
