Department of Ophthalmology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Int J Obes (Lond). 2010 Jul;34(7):1209-17. doi: 10.1038/ijo.2010.32. Epub 2010 Feb 16.
To investigate the relationship between the metabolic syndrome and intraocular pressure (IOP).
An observational study was conducted in a medical health checkup program at a general hospital. This study involved 14 003 apparently healthy Japanese men and women, 18-83 years of age, with a mean IOP of 14.8 (3.0) mm Hg. IOP was examined by noncontact tonometer. High-ocular tension was defined as IOP >21 mm Hg without optic-disc abnormalities or history of receiving any anti-glaucoma therapy. Modified criteria of the revised National Cholesterol Education Program Adult Treatment Panel III (rATPIII), the new International Diabetes Federation definition, and the Japan Society for The Study of Obesity definition were used to characterize the metabolic syndrome. Air temperature was assessed from the Gifu Meteorological Observatory, Gifu, Japan.
In the male and female subjects, mean IOP and the prevalence of high-ocular tension became high in direct correlation with the increased number of metabolic syndrome components. To analyze by logistic regression, the metabolic syndrome defined by rATPIII was positively and maximum temperature was negatively correlated with high-ocular tension in males (adjusted odds ratio: 2.0 [95% confidence interval, CI, 1.43-2.78] and 0.63 [95% CI, 0.54-0.73], respectively) and in females (adjusted odds ratio: 7.09 [95% CI, 3.74-13.43] and 0.67 [95% CI, 0.53-0.87], respectively). Three of five metabolic syndrome components (fasting plasma glucose, blood pressure, and triglycerides) were related to high-ocular tension.
The metabolic syndrome is a risk factor for high-ocular tension.
探讨代谢综合征与眼内压（IOP）的关系。
本研究为在一家综合医院进行的医学健康检查计划中的观察性研究。共纳入 14003 名年龄在 18-83 岁之间的日本籍健康男女，平均 IOP 为 14.8（3.0）mmHg。采用非接触眼压计测量 IOP。高眼压定义为 IOP＞21mmHg 且无视盘异常或接受任何抗青光眼治疗史。采用改良的美国胆固醇教育计划成人治疗专家组第三次报告（rATPIII）、新国际糖尿病联盟定义和日本肥胖学会定义来描述代谢综合征。采用日本岐阜气象观测站的气温评估数据。
在男性和女性受试者中，随着代谢综合征成分数量的增加，平均 IOP 和高眼压的患病率呈直线上升。通过逻辑回归分析，rATPIII 定义的代谢综合征与男性（调整后比值比：2.0[95%置信区间，CI：1.43-2.78]）和女性（调整后比值比：7.09[95%CI：3.74-13.43]）的高眼压呈正相关，而最高温度与高眼压呈负相关（调整后比值比：0.63[95%CI：0.54-0.73]）。五个代谢综合征成分中的三个（空腹血糖、血压和甘油三酯）与高眼压有关。
代谢综合征是高眼压的一个危险因素。
