Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Division of Epidemiology, National Cancer Center Institute for Cancer Control, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Sci Rep. 2022 Oct 19;12(1):17493. doi: 10.1038/s41598-022-22301-1.
Although a positive link between hypertension and intraocular pressure (IOP) has been suggested, the individual effects of systolic and diastolic blood pressure (SBP and DBP, respectively) on IOP remain unclear, particularly among Japanese populations. Here, we conducted a large-scale, cross-sectional study to determine individual and combined effects of SBP/DBP and hypertension on IOP. In total, 6783 Japanese people aged over 40 years underwent systemic and ophthalmological examinations, including measurements of blood pressure and IOP, conducted using non-contact tonometers. After adjusting for a priori known confounding factors, SBP and DBP levels were found to be positively correlated with IOP levels. The multivariable-adjusted odds ratio when comparing the hypertensive and normotensive groups for the prevalence of ocular hypertension was 1.88 (95% confidence interval, 1.14-3.08). When analysing the combined effects of SBP and DBP on ocular hypertension, SBP elevation had a greater effect on ocular hypertension than DBP increase. In conclusion, SBP and DBP levels and the prevalence of systemic hypertension were found to be positively associated with IOP levels and the prevalence of ocular hypertension in an ophthalmologically healthy Japanese population. Our findings suggest that systemic blood pressure control may be key for controlling IOP.
虽然已经有人提出高血压与眼内压(IOP)之间存在正相关关系,但收缩压和舒张压(分别为 SBP 和 DBP)对 IOP 的个体影响仍不清楚,特别是在日本人群中。在这里,我们进行了一项大规模的横断面研究,以确定 SBP/DBP 和高血压对 IOP 的单独和联合影响。共有 6783 名年龄在 40 岁以上的日本人接受了系统和眼科检查,包括使用非接触眼压计测量血压和 IOP。在调整了预先确定的混杂因素后,发现 SBP 和 DBP 水平与 IOP 水平呈正相关。与正常血压组相比,高血压组的眼部高血压患病率的多变量调整比值比为 1.88(95%置信区间,1.14-3.08)。当分析 SBP 和 DBP 对眼部高血压的联合影响时,SBP 升高对眼部高血压的影响大于 DBP 升高。总之,在一个眼科健康的日本人群中,SBP 和 DBP 水平以及系统性高血压的患病率与 IOP 水平和眼部高血压的患病率呈正相关。我们的研究结果表明,全身血压控制可能是控制 IOP 的关键。