地骨皮醇对脓毒症小鼠模型的保护作用：增强白细胞介素-10。
Protective effect of decursinol on mouse models of sepsis: enhancement of interleukin-10.
机构信息
Department of Pharmacology, College of Medicine, Institute of Natural Medicine, IDMRC, Hallym University, Chuncheon 200-702, Korea.
出版信息
Korean J Physiol Pharmacol. 2008 Apr;12(2):79-81. doi: 10.4196/kjpp.2008.12.2.79. Epub 2008 Apr 30.
Abstract
The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of mice with decursinol (50 mg/kg) markedly enhanced the LPS/GalN-induced increase of plasma interleukin-10 (IL-10) levels, without affecting plasma TNF-alpha, IL-6 and IL-12 levels. These results suggest that decursinol could be effective for prevention or treatment of sepsis.
摘要
研究了滇乌碱对各种脓毒症模型的作用。腹腔内给予不同剂量滇乌碱（1~100mg/kg）预处理可有效抑制三种实验性脓毒症小鼠模型（脂多糖[LPS]/D-半乳糖胺[GalN]、高剂量 LPS（20mg/kg）和盲肠结扎穿刺术[CLP]）引起的致死率。腹腔内给予滇乌碱（50mg/kg）预处理可显著增强 LPS/GalN 诱导的血浆白细胞介素-10（IL-10）水平的升高，而不影响 TNF-α、IL-6 和 IL-12 水平。这些结果表明滇乌碱可有效预防或治疗脓毒症。
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