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本文引用的文献

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Sepsis in the 21st century: recent definitions and therapeutic advances.21世纪的脓毒症：最新定义与治疗进展
Am J Emerg Med. 2007 Jun;25(5):564-71. doi: 10.1016/j.ajem.2006.08.015.
2
Boosting interleukin-10 production: therapeutic effects and mechanisms.增强白细胞介素-10的产生：治疗效果与机制
Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):465-75. doi: 10.2174/156800805774912926.
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Biology of interleukin-10 and its regulatory roles in sepsis syndromes.
Crit Care Med. 2005 Dec;33(12 Suppl):S468-71. doi: 10.1097/01.ccm.0000186268.53799.67.
4
Interleukin-10 and related cytokines and receptors.白细胞介素-10及相关细胞因子和受体。
Annu Rev Immunol. 2004;22:929-79. doi: 10.1146/annurev.immunol.22.012703.104622.
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Therapeutic effects of lysophosphatidylcholine in experimental sepsis.溶血磷脂酰胆碱在实验性脓毒症中的治疗作用
Nat Med. 2004 Feb;10(2):161-7. doi: 10.1038/nm989. Epub 2004 Jan 11.
6
Protection against beta-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice.长期给予小鼠当归提取物或紫花前胡醇对β-淀粉样肽诱导的记忆损伤的保护作用。
Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):25-30. doi: 10.1016/S0278-5846(03)00168-4.
7
Antinociceptive mechanisms of orally administered decursinol in the mouse.小鼠口服 decursinol 的抗伤害感受机制。
Life Sci. 2003 Jun 13;73(4):471-85. doi: 10.1016/s0024-3205(03)00311-4.
8
Effects of ginsenoside Rd and decursinol on the neurotoxic responses induced by kainic acid in mice.人参皂苷Rd和紫花前胡醇对红藻氨酸诱导的小鼠神经毒性反应的影响。
Planta Med. 2003 Mar;69(3):230-4. doi: 10.1055/s-2003-38475.
9
Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin.吡咯烷二硫代氨基甲酸盐可增强白细胞介素-10的生成，抑制肿瘤坏死因子-α、巨噬细胞炎性蛋白-1α、白细胞介素-12的生成以及一氧化氮的产生，并可对内毒素的致死效应起到保护作用。
Shock. 1998 Jul;10(1):49-53. doi: 10.1097/00024382-199807000-00009.
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Regulation of interleukin-10 production by beta-adrenergic agonists.β-肾上腺素能激动剂对白细胞介素-10产生的调节
Eur J Immunol. 1996 Nov;26(11):2601-5. doi: 10.1002/eji.1830261110.

地骨皮醇对脓毒症小鼠模型的保护作用：增强白细胞介素-10。

Protective effect of decursinol on mouse models of sepsis: enhancement of interleukin-10.

机构信息

Department of Pharmacology, College of Medicine, Institute of Natural Medicine, IDMRC, Hallym University, Chuncheon 200-702, Korea.

出版信息

Korean J Physiol Pharmacol. 2008 Apr;12(2):79-81. doi: 10.4196/kjpp.2008.12.2.79. Epub 2008 Apr 30.

DOI:10.4196/kjpp.2008.12.2.79
PMID:20157398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2817538/
Abstract

The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of mice with decursinol (50 mg/kg) markedly enhanced the LPS/GalN-induced increase of plasma interleukin-10 (IL-10) levels, without affecting plasma TNF-alpha, IL-6 and IL-12 levels. These results suggest that decursinol could be effective for prevention or treatment of sepsis.

摘要

研究了滇乌碱对各种脓毒症模型的作用。腹腔内给予不同剂量滇乌碱（1~100mg/kg）预处理可有效抑制三种实验性脓毒症小鼠模型（脂多糖[LPS]/D-半乳糖胺[GalN]、高剂量 LPS（20mg/kg）和盲肠结扎穿刺术[CLP]）引起的致死率。腹腔内给予滇乌碱（50mg/kg）预处理可显著增强 LPS/GalN 诱导的血浆白细胞介素-10（IL-10）水平的升高，而不影响 TNF-α、IL-6 和 IL-12 水平。这些结果表明滇乌碱可有效预防或治疗脓毒症。