Hands Sarah L, Proud Christopher G, Wyttenbach Andreas
School of Biological Sciences, University of Southampton, Southampton, Boldrewood Campus, Basset Crescent East, SO16 7PX, UK.
Aging (Albany NY). 2009 Jul 20;1(7):586-97. doi: 10.18632/aging.100070.
The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
由于衰老与许多人类疾病相关，目前调节衰老的分子和细胞机制正受到密切关注。营养感应TOR途径正成为衰老的关键调节因子。TOR信号传导很复杂，会影响几个关键的细胞功能，其中两个对衰老有明显影响的功能是蛋白质合成和自噬。在本文中，我们讨论了这两个过程在衰老中的相对重要性，确定了TOR如何调节翻译和自噬，并推测了TOR信号网络与衰老途径之间的联系。
