干扰素 β 预处理的流感病毒感染的人树突状细胞的免疫反应建模。
Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells.
机构信息
Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA.
出版信息
Biophys J. 2010 Feb 17;98(4):505-14. doi: 10.1016/j.bpj.2009.10.049.
Abstract
The pretreatment of human dendritic cells with interferon-beta enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational model of cellular immune response that elucidates its mechanism and its dynamics in interferon-pretreated dendritic cells, and provides insights into the effects of duration and strength of pretreatment.
摘要
干扰素-β预处理人树突状细胞可增强其对流感病毒感染的免疫反应。我们在预处理和病毒感染后 13 小时的时间内测量了该反应中几个关键分子的表达水平。它们的激活谱反映了干扰素诱导和干扰素信号通路中存在负反馈和正反馈环。基于这些测量，我们开发了一个全面的细胞免疫反应计算模型，阐明了其在预处理树突状细胞中的机制和动态，并深入了解了预处理的持续时间和强度的影响。
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2
RNA recognition and signal transduction by RIG-I-like receptors.
Immunol Rev. 2009 Jan;227(1):54-65. doi: 10.1111/j.1600-065X.2008.00727.x.
3
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.
Science. 2009 Feb 20;323(5917):1070-4. doi: 10.1126/science.1168352. Epub 2009 Jan 1.
4
Antiviral-activated dendritic cells: a paracrine-induced response state.
J Immunol. 2008 Nov 15;181(10):6872-6881. doi: 10.4049/jimmunol.181.10.6872.
5
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PLoS Pathog. 2008 Oct;4(10):e1000193. doi: 10.1371/journal.ppat.1000193. Epub 2008 Oct 31.
6
Design principles of biochemical oscillators.
Nat Rev Mol Cell Biol. 2008 Dec;9(12):981-91. doi: 10.1038/nrm2530. Epub 2008 Oct 30.
7
Model-based analysis of interferon-beta induced signaling pathway.
Bioinformatics. 2008 Oct 15;24(20):2363-9. doi: 10.1093/bioinformatics/btn400. Epub 2008 Aug 19.
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Interferon-inducible antiviral effectors.
Nat Rev Immunol. 2008 Jul;8(7):559-68. doi: 10.1038/nri2314.
9
Protein tyrosine phosphatases in the JAK/STAT pathway.
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