Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110-1093, USA.
Psychiatr Clin North Am. 2010 Mar;33(1):107-24. doi: 10.1016/j.psc.2009.10.003.
Addictions include a group of common, heritable psychiatric illnesses that have multiple psychiatric and medical comorbidities. Robust genetic associations have been found for alcohol dependence, nicotine dependence, and cocaine dependence. Common genetic associations have been found between alcohol dependence and aerodigestive cancers and between nicotine dependence and lung disease. These associations highlight the importance of understanding the genetics of substance dependence in the context of its multiple medical and psychiatric comorbidities.
成瘾包括一组常见的、可遗传的精神疾病，这些疾病有多种精神和医学共病。已经发现酒精依赖、尼古丁依赖和可卡因依赖有很强的遗传关联。已经发现酒精依赖和呼吸道癌症之间以及尼古丁依赖和肺部疾病之间有共同的遗传关联。这些关联突出了在其多种医学和精神共病的背景下理解物质依赖的遗传学的重要性。
