Department of Pediatrics, University of Washington, Seattle, Washington, USA.
J Adolesc Health. 2010 Mar;46(3):284-91. doi: 10.1016/j.jadohealth.2009.08.001. Epub 2009 Oct 13.
The goal of this study was to determine whether adolescent offspring of mothers with chronic fatigue syndrome (CFS) have higher prevalence of CFS and report more fatigue, greater pain sensitivity, more sleep problems, and poorer cardiopulmonary fitness in comparison with offspring with no exposure to maternal CFS.
A total of 26 adolescent offspring of 20 mothers diagnosed with CFS were compared with 45 adolescent offspring of 30 age-matched healthy control mothers. Study measures included structured interviews and medical and laboratory examinations for CFS; tender point examination; maximum oxygen uptake and perceived exertion; dolorimetry pain ratings; and questionnaires on fatigue severity and sleepiness.
In comparison with offspring of healthy mothers, those exposed to mothers with CFS reported higher prevalence of fatigue of at least 1-month duration (23% vs. 4%), fatigue of 6 months or longer (15% vs. 2%), and met criteria for CFS (12% vs. 2%), although these differences only approached statistical significance. CFS and healthy mothers differed on almost all study outcomes, but offspring groups did not differ on measures of current fatigue severity, pain sensitivity, sleep, mean number of tender points, and cardiopulmonary fitness.
The higher prevalence of fatiguing states in offspring of CFS mothers, despite the lack of statistical significance, suggests that familial factors may potentially play a role in developing chronically fatiguing states. Alternately, perturbations in pain sensitivity and cardiopulmonary fitness may be consequences of CFS. Future studies should focus on examining the impact of maternal CFS and associated disability on psychosocial functioning of offspring.
本研究旨在确定患有慢性疲劳综合征（CFS）的母亲的青少年子女是否比未接触过母体 CFS 的子女更容易出现 CFS，且更容易出现疲劳、更高的疼痛敏感性、更多的睡眠问题和较差的心肺功能。
将 20 名患有 CFS 的母亲的 26 名青少年子女与 30 名年龄匹配的健康对照母亲的 45 名青少年子女进行比较。研究措施包括 CFS 的结构化访谈和医学及实验室检查；压痛检查；最大摄氧量和感知用力；痛觉测定；疲劳严重程度和嗜睡问卷。
与健康母亲的子女相比，暴露于患有 CFS 的母亲的子女报告了至少 1 个月的疲劳（23%对 4%）、6 个月或更长时间的疲劳（15%对 2%）和符合 CFS 标准（12%对 2%）的发生率更高，尽管这些差异仅接近统计学意义。CFS 母亲和健康母亲在几乎所有的研究结果上都存在差异，但子女组在当前疲劳严重程度、疼痛敏感性、睡眠、压痛点数和心肺功能等指标上没有差异。
尽管没有统计学意义，但 CFS 母亲的子女中出现疲劳状态的比例较高，这表明家庭因素可能在慢性疲劳状态的发展中发挥作用。或者，疼痛敏感性和心肺功能的改变可能是 CFS 的后果。未来的研究应重点研究母体 CFS 及其相关残疾对子女心理社会功能的影响。
