Research Department and Neuropsychiatric Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico.
J Neuropsychiatry Clin Neurosci. 2010 Winter;22(1):63-9. doi: 10.1176/jnp.2010.22.1.63.
The authors aim to explore psychiatric disorders in Mexican patients with multiple sclerosis. The Structured Clinical Interview for DSM-IV Axis I Disorders, the Montgomery-Asberg Depression Rating Scale, and the Hamilton Anxiety Rating Scale were administered to 37 consecutive multiple sclerosis patients and 37 healthy comparison subjects. The multiple sclerosis group had higher rates of any axis I disorder (OR 1.97; 95% CI=1.78-3.306). The most common comorbid diagnoses were depressive disorders (46% of the multiple sclerosis cases) with higher anxiety scores (p=0.001). No correlations between psychiatric variables, number of relapses, and clinical course of multiple sclerosis were found.
作者旨在探讨墨西哥多发性硬化症患者的精神障碍。对 37 例连续多发性硬化症患者和 37 例健康对照者进行了 DSM-IV 轴 I 障碍的结构临床访谈、蒙哥马利-阿斯伯格抑郁评定量表和汉密尔顿焦虑评定量表的评估。多发性硬化症组的任何轴 I 障碍发生率更高（OR 1.97；95%CI=1.78-3.306）。最常见的合并诊断是抑郁障碍（多发性硬化症病例的 46%），伴有更高的焦虑评分（p=0.001）。未发现精神科变量、复发次数和多发性硬化症的临床病程之间存在相关性。
