β-内酰胺类抗生素：从抗菌作用到耐药性和细菌学。
Beta-lactam antibiotics: from antibiosis to resistance and bacteriology.
机构信息
Department of Biological Sciences, Florida International University, Miami, FL, USA.
出版信息
APMIS. 2010 Jan;118(1):1-36. doi: 10.1111/j.1600-0463.2009.02563.x.
Abstract
This review focuses on the era of antibiosis that led to a better understanding of bacterial morphology, in particular the cell wall component peptidoglycan. This is an effort to take readers on a tour de force from the concept of antibiosis, to the serendipity of antibiotics, evolution of beta-lactam development, and the molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. In spite of this knowledge, which has enabled design of new even more effective therapeutics to combat bacterial infection and has provided new research tools, antibiotic resistance remains a worldwide health care problem.
摘要
这篇综述重点介绍了抗生素时代，这一时期使人们对细菌形态学有了更好的理解，特别是细胞壁成分肽聚糖。本文旨在带领读者深入了解抗生素的概念、抗生素的偶然发现、β-内酰胺类药物的发展演变以及抗生素耐药性的分子生物学。这些研究领域使人们对微生物学有了更深入的理解，特别是在细菌细胞壁合成和回收方面。尽管有了这些知识，设计出了更新、更有效的治疗方法来对抗细菌感染，并提供了新的研究工具，但抗生素耐药性仍然是一个全球性的医疗保健问题。
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The sensitivity of bacteria to the action of penicillin.细菌对青霉素作用的敏感性。
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Staphylococcal infection due to penicillin-resistant strains.由耐青霉素菌株引起的葡萄球菌感染。
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AmpC beta-lactamases.AmpC β-内酰胺酶
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Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes.假单胞菌基因组数据库：助力微生物基因组的用户友好型全面比较。
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EcoCyc: a comprehensive view of Escherichia coli biology.《大肠杆菌代谢数据库（EcoCyc）：大肠杆菌生物学全景》
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Infection by penicillin-resistant staphylococci.耐青霉素葡萄球菌感染。
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Benefit of having multiple ampD genes for acquiring beta-lactam resistance without losing fitness and virulence in Pseudomonas aeruginosa.铜绿假单胞菌中多个ampD基因在获得β-内酰胺抗性同时不丧失适应性和毒力的益处。
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Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle.细菌DD-肽酶与肽聚糖模拟配体复合物的晶体结构：底物特异性之谜。
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