Lindberg U B, Leibel R L, Silfverstolpe G, Hirsch J, Björntorp P, Rébuffé-Scrive M
Department of Obstetrics and Gynecology, Sahlgren's Hospital, University of Göteborg, Sweden.
Horm Metab Res. 1991 Jan;23(1):25-9. doi: 10.1055/s-2007-1003603.
Adipose tissue metabolism was studied in needle biopsies from femoral and abdominal subcutaneous depots, in 12 healthy young women, during early (9-11 weeks) pregnancy, and 6 weeks after a legal abortion. Both during pregnant and non-pregnant conditions, a higher lipoprotein lipase (LPL) activity was seen in the femoral compared to the abdominal region, but the LPL activity was not influenced by early pregnancy. Rates of fatty acid esterification and acylglyceride synthesis were not different between regions, nor affected by pregnancy. The stimulatory effect of norepinephrine (10(-7) M) on lipolysis was significantly greater in the abdominal than in the femoral region in both the pregnant and non-pregnant condition. This difference was apparently due to higher alpha-adrenergic activity in the femoral region. Pregnancy per se had no effect on lipolytic response to norepinephrine. These findings indicate that lipid accumulation is favoured in the femoral region in young women both during pregnant and non-pregnant conditions.
在12名健康年轻女性中，对她们在妊娠早期（9 - 11周）以及合法流产后6周时，取自股部和腹部皮下脂肪库的针吸活检组织进行脂肪组织代谢研究。在妊娠和非妊娠状态下，股部的脂蛋白脂肪酶（LPL）活性均高于腹部区域，但LPL活性不受妊娠早期的影响。脂肪酸酯化率和酰基甘油合成率在不同区域之间无差异，也不受妊娠影响。在妊娠和非妊娠状态下，去甲肾上腺素（10⁻⁷ M）对腹部脂肪分解的刺激作用均显著大于股部。这种差异显然是由于股部区域较高的α-肾上腺素能活性所致。妊娠本身对去甲肾上腺素的脂肪分解反应无影响。这些发现表明，在年轻女性中，无论妊娠与否，股部区域都更有利于脂质蓄积。
