Rebuffé-Scrive M, Enk L, Crona N, Lönnroth P, Abrahamsson L, Smith U, Björntorp P
J Clin Invest. 1985 Jun;75(6):1973-6. doi: 10.1172/JCI111914.
Adipose tissue lipolysis and lipoprotein lipase (LPL) activity were studied in biopsies from the femoral and abdominal depots in healthy women during early or late menstrual cycle, pregnancy, and the lactation period. When the differences in cell size were taken into account, basal lipolysis was similar in both regions in nonpregnant women. During lactation, however, lipolysis was significantly higher in the femoral region. The lipolytic effect of noradrenaline (10(-6) M) was significantly less in the femoral region in the nonpregnant women and during early pregnancy. However, the lipolytic response was the same in both regions in lactating women. LPL activity was higher in the femoral than in the abdominal region except during lactation when a marked decrease in the LPL activity was seen in the femoral region. The LPL activity in the abdominal region remained unchanged in all patient groups. The results imply that in both nonpregnant and pregnant women lipid assimilation is favored in the femoral depot. During lactation, however, the metabolic pattern changes; the LPL activity decreases and lipid mobilization increases in this depot. These changes are much less pronounced in the abdominal region. Thus, fat cells from different regions show a differential response during pregnancy and lactation. These results suggest that the adipose tissue in different regions may have specialized functions.
对健康女性在月经周期早期或晚期、孕期及哺乳期时，取自股骨和腹部脂肪储存部位的活检组织进行了脂肪组织脂解作用和脂蛋白脂肪酶（LPL）活性的研究。若将细胞大小差异考虑在内，非孕期女性两个部位的基础脂解作用相似。然而，在哺乳期，股骨部位的脂解作用明显更高。在非孕期女性及孕早期，去甲肾上腺素（10⁻⁶ M）在股骨部位的脂解作用明显较弱。然而，哺乳期女性两个部位的脂解反应相同。除哺乳期股骨部位LPL活性显著降低外，股骨部位的LPL活性高于腹部。腹部的LPL活性在所有患者组中均保持不变。结果表明，在非孕期和孕期女性中，股骨部位更有利于脂质同化。然而，在哺乳期，代谢模式发生变化；该储存部位的LPL活性降低，脂质动员增加。这些变化在腹部区域则不太明显。因此，不同区域的脂肪细胞在孕期和哺乳期表现出不同的反应。这些结果表明，不同区域的脂肪组织可能具有特殊功能。
